Is SV40 a vector?
Simian virus-40 (SV40), an icosahedral papovavirus, has recently been modified to serve as a gene delivery vector. Preliminary therapeutic results obtained both in tissue culture cells and in animal models for heritable and acquired diseases indicate that rSV40 vectors are promising gene transfer vehicles.
What is a transducing vector?
If DNA or RNA is introduced into cells by using viral vector carriers, then the technique is called Transduction, and the resulting cells are said to be transduced! It includes virus-based vectors such as lentiviral vectors, adeno-associated viruses (AAV) and adenoviruses.
What is the role of SV40 promoter?
The early promoter of the simian virus 40 (SV40) has been used as a model eukaryotic promoter for the study of DNA sequence elements and cellular factors that are involved in transcriptional control and initiation. Some of these elements are present in cellular genes, and may exhibit tissue-specificity in their action.
What is a transducing particle?
A defective phage carrying part of the Host genome in place of part of the phage genome.
What is a transducing phage?
Transduction begins when a phage that has infected a bacterium mistakenly packages a segment of the host cell’s chromosome into its capsid, or head, instead of its own DNA. This phage is called a transducing phage since it can transfer the genetic material of the first bacterium into the second.
Is SV40 a promoter?
The early promoter of the simian virus 40 (SV40) has been used as a model eukaryotic promoter for the study of DNA sequence elements and cellular factors that are involved in transcriptional control and initiation.