What does JAK-STAT pathway do?
The JAK/STAT pathway regulates embryonic development and is involved in the control of processes such as stem cell maintenance, haematopoiesis and the inflammatory response. The pathway transduces signals from cytokines, interleukins and growth factors that act through a number of transmembrane receptor families.
Why is the JAK-STAT pathway important?
JAK-STAT signalling plays an important role in animal development. The pathway can promote blood cell division, as well as differentiation (the process of a cell becoming more specialised). In some flies with faulty JAK genes, too much blood cell division can occur, potentially resulting in leukaemia.
What hormones use Jak-Stat pathway?
Growth hormone activates the Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signaling pathway, and recent studies have provided a new understanding of the mechanism of JAK2 activation by growth hormone binding to its receptor.
What is JAK in immunology?
The Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway has a crucial role in the control of immune responses. The activity of JAKs and STATs is regulated by various post-translational modifications, including phosphorylation, methylation, ubiquitylation and ISGylation.
What hormones use Jak Stat pathway?
What is Jak in immunology?
What is distinctive about Jak Stat cytokine receptors?
Jaks (Janus Kinases) are a unique class of tyrosine kinases that associate with cytokine receptors. Upon ligand binding, they activate members of the Signal Transducers and Activators of Transcription (STAT) family through phosphorylation on a single tyrosine.
What does JAK-STAT stand for?
Acronym. Definition. JAK-STAT. Janus Kinase and Signal Transducer and Activator of Transcription (cytology)
What are the transcriptional factors that are affected by Jak-Stat pathway?
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway mediates cellular responses to cytokines (e.g., IL-6) and growth factors (e.g., EGF).