Can Methysergide cause retroperitoneal fibrosis?
Methysergide is no longer a favored treatment as its use may cause retroperitoneal fibrosis as well as cardiac valvular lesions and intimal proliferation in blood vessels.
What is idiopathic retroperitoneal fibrosis?
Idiopathic retroperitoneal fibrosis (RPF), reviewed herein, is a rare fibro-inflammatory disease that develops around the abdominal aorta and the iliac arteries, and spreads into the adjacent retroperitoneum, where it frequently causes ureteral obstruction and renal failure.
What is Ormond’s disease?
Idiopathic retroperitoneal fibrosis also known as Ormonds disease is a rare disorder characterized by the development of fibrotic tissue in the retroperitoneum involving the abdominal aorta and iliac arteries, ureters and the inferior vena cava.
Is retroperitoneal fibrosis cancerous?
Retroperitoneal fibrosis (RPF) is the abnormal growth of white and ‘woody’ tissue on and around the structures of the abdomen that are outside the peritoneum. Occasionally, the tissue can be cancerous. RPF is also known as Ormond’s disease.
Which drugs cause retroperitoneal fibrosis?
The particular incidence, in the last four decades past century, of the RPF due to long-term use of ergot alkaloid derivatives (ergotamine, methysergide, pergolide, bromocriptine, cabergoline) and specific L-dopa derived agents, such as methyldopa, as well as to different analgesics, came progressively down given that …
Which ergot alkaloid is most likely to cause retroperitoneal fibrosis during chronic therapy?
Thirty percent of retroperitoneal fibrosis cases are a result of an identifiable cause. Numerous drugs have been implicated in the development of RPF. Drugs such as methysergide (Sansert) and other ergot alkaloids are most commonly associated with this condition.
Does retroperitoneal fibrosis go away?
In some cases, physicians may wrap a layer of fat around the ureter in an attempt to prevent the recurrence of ureter obstruction. In some reported cases, retroperitoneal fibrosis has subsided on its own without treatment (spontaneous resolution).
What causes retroperitoneal fibrosis?
Risk factors for retroperitoneal fibrosis include asbestos exposure, smoking, tumor , infection, trauma, radiotherapy, surgery, and use of certain drugs. Treatment may include corticosteroids , tamoxifen, stents or surgery.
What drugs can cause retroperitoneal fibrosis?
analgesics: particularly phenacetin, paracetamol and aspirin; hydralazine; antitumoral chemotherapeutics, among which carboplatin and methotrexate; bio-pharmaceutical agents, such as the tumor necrosis factor-α (TNF-α) receptor blocker Etanercept and, questionably, the anti-TNF-α monoclonal antibody (Infliximab).
Is there a connection between retroperitoneal fibrosis and methysergide 3?
Reports (1–6) of a suspected causal relationship between therapy with methysergide 3 and the occurrence of retroperitoneal fibrosis (R.F.) prompted us to record three such cases recently observed.
What kind of condition is retroperitoneal fibrosis ( RPF )?
Retroperitoneal fibrosis (RPF), is a condition that has previously been described as chronic periaortitis . It is an uncommon fibrotic reaction in the retroperitoneum that typically presents with ureteric obstruction.
Which is more sensitive MRI or CT for retroperitoneal fibrosis?
MRI has been reported to be as sensitive as CT in its assessment of retroperitoneal fibrosis with the added advantage of high contrast resolution between closely apposed retroperitoneal structures.