What is Oncocytic variant of papillary thyroid carcinoma?
The oncocytic variant of PTC is comprised of oncocytic cells with classic nuclear features of PTC such as enlarged, elongated, irregular nuclei, which are also clear, crowded, and overlapping with prominent grooves and pseudoinclusions (9,12–17).
Which is the most common site of metastases for papillary thyroid cancer?
It typically spreads via lymphatic extension. The rate of regional PTC metastasis to the neck is relatively high, while metastases outside the deep cervical chain are rare. Distant metastases are found in only 1% of patients with PTC at the time of surgery; the two most common sites are the lung and bone.
What does Oncocytic mean?
Definition. Oncocytic change is defined as cellular enlargement characterised by an abundant eosinophilic granular cytoplasm as a result of the accumulation of altered mitochondria.
What is Oncocytic neoplasm?
Oncocytoma is a term generally used to describe a neoplasm of the renal parenchyma consisting of well-differentiated cells with prominently eosinophilic granular cytoplasm. We report our experience with such tumors and with 4 cases of granular cell carcinoma (grade 2).
What happens when you have papillary thyroid carcinoma?
Distant metastasis of papillary thyroid cancer is uncommon, but when it does occur, it may spread to the lungs, liver, and bone. Papillary thyroid cancers that invade the surrounding tissues next to the thyroid gland have a much worse prognosis because of a high local recurrence rate.
Is papillary thyroid carcinoma benign or malignant?
Most of the time, the lump will be benign and harmless. It could be a simple buildup of excess thyroid cells that have formed a mass of tissue. Sometimes the lump is a papillary carcinoma of the thyroid.
Is there a diffuse sclerosing variant of papillary thyroid?
Background: The diffuse sclerosing variant of papillary thyroid carcinoma (DSPC) is a relatively rare variant of papillary thyroid cancer. Large studies of patients with DSPC have been infrequently performed, and controversy still exists concerning some DSPC features and outcomes.
Are there different types of papillary thyroid cancer?
There are different variants of papillary thyroid cancer: classic, follicular, tall-cell, diffuse sclerosing, noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Thyroidectomy: surgery to remove the entire thyroid gland.
What are the risks of diffuse sclerosing thyroid cancer?
Patients diagnosed with the diffuse sclerosing variant of papillary thyroid cancer present with aggressive features and high rates of extensive disease. The risk of recurrence is similar to other high-risk papillary thyroid cancers, despite extensive initial surgery and radioactive iodine ablation.
Which is more aggressive tall cell or papillary thyroid cancer?
Overall, papillary cancer generally has an excellent prognosis. However, some of its variants, such as tall cell and insular variants, may be more aggressive. Some studies suggest that the diffuse sclerosing variant of papillary thyroid cancer also can be more aggressive.