What is succinylcholine made from?
Succinylcholine is a quaternary ammonium ion that is the bis-choline ester of succinic acid. It has a role as a neuromuscular agent, a muscle relaxant and a drug allergen. It is a quaternary ammonium ion and a succinate ester.
What drug class is succinylcholine?
Anectine belongs to a class of drugs called Neuromuscular Blockers, Depolarizing.
Is succinylcholine cholinergic?
Succinylcholine (suxamethonium) is a highly potent agonist at the neuromuscular junction (NMJ) nicotinic acetylcholine receptors. It is a direct cholinergic agonist in that it binds to the same binding site as the endogenous transmitter acetylcholine and activates the receptor in the same manner as acetylcholine.
What is succinylcholine in pharmacology?
Succinylcholine is a skeletal muscle relaxant for intravenous (IV) administration indicated as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
Where is succinylcholine metabolized?
Succinylcholine is rapidly metabolized by plasma cholinesterase in the bloodstream to succinylmonocholine, which is then further hydrolyzed (albeit more slowly) to succinic acid and choline. Approximately 10% of an administered dose is excreted unchanged in the urine.
What is the antidote for succinylcholine?
Malignant hyperthermia (MH) events are uncommon but potentially lethal adverse responses to volatile anesthetic agents or succinylcholine. Some question whether succinylcholine without volatile anesthetics triggers MH. Dantrolene is an effective antidote.
Is succinylcholine used for intubation?
Succinylcholine remains the drug of choice for satisfactory rapid-sequence tracheal intubation.
Which is the chloride form of succinylcholine?
Succinylcholine Chloride is the chloride salt form of succinylcholine, a quaternary ammonium compound and depolarizing agent with short-term muscle relaxant properties.
How does succinylcholine work as a muscle relaxer?
More… Succinylcholine is a quaternary ammonium compound and depolarizing agent with short-term muscle relaxant properties. Succinylcholine binds to nicotinic receptors at the neuromuscular junction and opening the ligand-gated channels in the same way as acetylcholine, resulting in depolarization and inhibition of neuromuscular transmission.
Where does succinylcholine chloride bind to nicotinic receptors?
Succinylcholine chloride binds to nicotinic receptors at the neuromuscular junction and opening the ligand-gated channels in the same way as acetylcholine, resulting in depolarization and inhibition of neuromuscular transmission.
What are the side effects of succinylcholine depolarization?
Succinylcholine. Depolarization may be prolonged due to succinylcholine’s resistance to acetylcholinesterases thereby leading to disorganized muscle contraction followed by skeletal muscle relaxation and flaccid paralysis.