What is the adverse effect of bleomycin?
The following side effects are common (occurring in greater than 30%) for patients taking bleomycin: Fever and chills. Skin reactions: redness, darkening of the skin, stretch marks on the skin, skin peeling, thickening of the skin, ulceration. Nail thickening, nail banding.
How long does it take for bleomycin to work on warts?
A total of 82 (96.47%) of the 85 warts treated with intralesional bleomycin in a dosage of 1 mg/mL in group A showed complete resolution after one or two injections within 12 weeks.
What are the long term effects of bleomycin?
The chemo drug bleomycin can damage the lungs, as can radiation therapy to the chest. This can lead to problems like shortness of breath, which might not show up until years after treatment. Smoking can also seriously damage the lungs, so it’s important that people who have had these treatments do not smoke.
Is bleomycin used for warts?
Bleomycin has been used to treat warts for several years. Bleomycin is also used to treatment some cancers. Unlike cancer treatment, wart treatment involves using very small amounts of Bleomycin on the surface of the skin of the wart. It is not given by mouth or in the veins.
Does bleomycin cause neurotoxicity?
Osmotic blood-brain barrier modification was used to increase delivery of bleomycin and 5-fluorouracil to the ipsilateral brain region, but the increased delivery was associated with evident neurotoxicity.
How does bleomycin work on warts?
Bleomycin is a glycopeptide antibiotic produced by the bacterium Streptomyces verticillus, mainly used as a chemotherapy drug, causing DNA strand breakage and preventing cell replication. Studies have shown to be effective for the treatment of resistant viral warts.
Do you lose your hair with bleomycin?
Bleomycin may cause a temporary loss of hair in some people. After treatment has ended, normal hair growth should return, although it may take several months. Side effects that affect your lungs (for example, cough and shortness of breath) may be more likely to occur if you smoke.
What do they inject into warts?
Cryotherapy with liquid nitrogen is a favorable option for many patients, with cure rates of 50 to 70 percent after three or four treatments. For recalcitrant warts, Candida or mumps skin antigen can be injected into the wart every three to four weeks for up to three treatments.
How effective is bleomycin?
Numerous reports have been published on the use of intralesional bleomycin for the treatment of recalcitrant warts with cure rates ranging from 14% to 99%. The majority of the data suggests that bleomycin is effective in over two-thirds of the reported cases with minimal side effects.
Are there any side effects to bleomycin injections?
There have been a few reports that show success in treating genital warts. The immediate side effects are swelling and redness due to the injection. A feeling of burning and pain may be felt right after injecting the solution. The pain may remain for up to 3 days at most.
How much bleomycin to use for a wart?
How to Use Intralesional Bleomycin with Warts. Doctors normally use the combination 1ml tuberculin syringe and an insulin syringe, because the surface of warts sometimes show leaking of the solution injected. The normal volume injected for every treatment is between 0.1 ml to 2 ml. Any more than that can cause higher risks in side effects.
How often do you have to give bleomycin injections?
The normal volume injected for every treatment is between 0.1 ml to 2 ml. Any more than that can cause higher risks in side effects. Additional injections may need to be given every three or four weeks until clearance has been achieved.
Is it safe to take bleomycin during pregnancy?
Because of the possibility of developing Raynaud phenomenon, it is recommended that intralesional bleomycin is not performed in patients with peripheral vascular disease or connective tissue disease. The use of bleomycin is not recommended in pregnancy and lactation because of the risks of the drug to the baby.