What does 5-aminosalicylic acid do?
This medication is used to treat a certain bowel disease (ulcerative colitis). It helps to reduce symptoms of ulcerative colitis such as diarrhea, rectal bleeding, and stomach pain. Mesalamine belongs to a class of drugs known as aminosalicylates. It works by decreasing swelling in the colon.
Is sulfasalazine an Aminosalicylate?
Sulfasalazine is a prodrug composed of 5-aminosalicylic acid (5-ASA) linked to sulfapyridine through an azo bond (figure 1).
What are oral 5 aminosalicylates?
What are 5-aminosalicylates? Aminosalicylates are anti-inflammatory agents used to treat inflammatory bowel disease and some forms of arthritis.
Is 5-ASA aspirin?
5-ASA are also known as Aminosalicylic acids. They are chemically related to aspirin, and work by damping down the inflammatory process, so allowing damaged tissue to heal. There are several types of 5-ASA drugs: sulphasalazine (brand name Salazopyrin®)
Is 5-ASA a Nsaid?
Mesalamine, also known as 5-aminosalicylic acid, is an anti-inflammatory drug, but as it does not have potent inhibitory effects on COX activity, is not considered an NSAID.
What class of drug is ASA?
Aspirin (acetylsalicylic acid) is a pharmaceutical drug used to reduce pain1,2 or inflammation. It is classified as a non-steroidal anti-inflammatory drug (NSAID). Aspirin can be used to treat: mild to moderate pain.
Which is not compatible with 5-aminosalicylic acid?
5-AMINOSALICYLIC ACID is incompatible with acids, acid chlorides, acid anhydrides, chloroformates and strong oxidizers. (NTP, 1992)
What happens when 5-aminosalicylic acid is heated?
When heated to decomposition it emits toxic fumes of carbon monoxide, carbon dioxide and nitrogen oxides. (NTP, 1992) 5-AMINOSALICYLIC ACID is incompatible with acids, acid chlorides, acid anhydrides, chloroformates and strong oxidizers.
Is there a 5-ASA that is not sulfasalazine?
Sulfasalazine is still used, however, some patients experience side effects due to the sulfa component (see below). Another form of 5-ASA is known as mesalamine, which does not contain a sulfa group. Approximately 90% of those with intolerance to sulfasalazine can tolerate mesalamine.
What are the side effects of aminosalicylates in IBD?
Overall, aminosalicylates are well tolerated and safe. All 5-ASA agents may cause headache, nausea, abdominal pain and cramping, loss of appetite, vomiting, rash, or fever. In addition, 5-ASA agents may cause diarrhea (less than 1% of users), which may be difficult to distinguish from increased IBD activity.