What is dabigatran etexilate mesylate?
Dabigatran is an anticoagulant that works by blocking a certain substance (a clotting protein called thrombin) in your blood. This helps to keep blood flowing smoothly in your body. Dabigatran should not be used to prevent blood clots from forming after artificial heart valve replacement.
What class of drug is dabigatran etexilate mesylate?
Dabigatran is in a class of anticoagulant medications called direct thrombin inhibitors. It works by preventing blood clots from forming in the body.
What is dabigatran for?
About dabigatran It’s used to treat people who have had a health problem caused by a blood clot, such as: a stroke. a heart attack. a blood clot in the leg (deep vein thrombosis, or DVT)
Is dabigatran etexilate generic?
dabigatran etexilate mesylate capsule;oral Note: No generic formulation of the following product is available.
Is dabigatran etexilate mesylate a blood thinner?
Pradaxa (dabigatran) is an anticoagulant that works by blocking the clotting protein thrombin. Pradaxa is used to prevent blood clots from forming because of a certain irregular heart rhythm (atrial fibrillation). Preventing these blood clots helps to reduce the risk of a stroke.
Does dabigatran lower blood pressure?
We present the case of a patient with hypertension and AF in which the interaction between losartan and acenocoumarol was associated with an irregular systolic BP control, but after switching to dabigatran, BP control improved.
What is the mechanism of action of dabigatran?
Mechanism of Action Pradaxa (dabigatran etexilate mesylate) is a competitive, direct thrombin inhibitor. Because thrombin (serine protease) enables the conversion of fibrinogen into fibrin during the coagulation cascade, its inhibition prevents the development of a thrombus.
Who makes dabigatran?
Boehringer Ingelheim Pharmaceuticals, Inc. Announces Updates to Prescribing Information for Pradaxa® (dabigatran etexilate mesylate) | boehringer-ingelheim.us.
What is the brand name for dabigatran?
Dabigatran is used to prevent blood clots from forming because of a certain irregular heart rhythm (atrial fibrillation). Preventing these blood clots helps to reduce the risk of a stroke. Dabigatran is available under the following different brand names: Pradaxa.
When is dabigatran contraindicated?
PRADAXA is contraindicated in patients with: Active pathological bleeding [see Warnings and Precautions (5.1) and Adverse Reactions (6.1)]. History of a serious hypersensitivity reaction to PRADAXA (e.g., anaphylactic reaction or anaphylactic shock) [see Adverse Reactions (6.1)].
Is dabigatran an antiplatelet?
Dabigatran significantly reduced coagulation activity and may have the potential to reduce cardiovascular events when added to dual antiplatelet treatment in the doses 110–150 mg twice daily.
Where is dabigatran absorbed?
Dabigatran is thought to be absorbed in the lower stomach and duodenum because of the rapid time to peak levels 21.
What is the control number for dabigatran etexilate capsules?
Dabigatran Etexilate Capsules 75 mg, 110 mg and 150 mg Dabigatran Etexilate (as Dabigatran Etexilate Mesylate) Anticoagulant APOTEX INC DATE OF PREPARATION: 150 Signet Drive October 10, 2017 Toronto, Ontario M9L 1T9 Control Number: 182812
What is the molecular formula for dabigatranetexilate mesylate?
Dabigatranetexilate mesylate drug substance is a BCS Class II (low solubility / high permeability). Solubility is pH dependednt (higher at pH < 3). Molecular Formula: C34H41N7O5· CH4O3S Molecular Weight (mesylate salt): 723.86 g/mol Molecular Weight (free base): 627.75 g/mol The approved drug substance retest interval is months.
What are the ingredients in prapo dabigatran etexilate capsules?
PrAPO-DABIGATRAN Dabigatran Etexilate Capsules PART I: HEALTH PROFESSIONAL INFORMATION SUMMARY PRODUCT INFORMATION Route of Administration Dosage Form/Strength All Nonmedicinal Ingredients Oral Capsules / 75 mg, 110 mg and 150 mg Fumaric Acid, Magnesium Stearate, and Mannitol.
When does the Cmax occur after taking dabigatran?
Dabigatran etexilate is a substrate of the efflux cell membrane transporter P-gp. After oral administration in healthy volunteers, the Cmax occurs at 1 hour post-administration in the fasted state.