What is type II Hyperlipoproteinemia?
Type II hyperlipoproteinemia: It is characterized by marked hypercholesterolemia. It includes several genetic diseases, such as familial hypercholesterolemia due to mutation of the gene for the LDL receptor and some diseases that may lead to the elevation of LDL and cholesterol.
What is the reason of Type II Hyperlipoproteinemia?
Type IIb hyperlipoproteinemia is caused by mutation in the receptor-binding domain of APOLIPOPROTEIN B-100 which is a major component of LOW-DENSITY LIPOPROTEINS and VERY-LOW-DENSITY LIPOPROTEINS resulting in reduced clearance of these lipoproteins.
What are the types of Hyperlipoproteinemia?
There are five types of primary hyperlipoproteinemia:
- Type 1 is an inherited condition.
- Type 2 runs in families.
- Type 3 is a recessively inherited disorder in which intermediate-density lipoproteins (IDL) accumulate in your blood.
- Type 4 is a dominantly inherited disorder.
- Type 5 runs in families.
What are the various types of Hyperlipidemias discuss each?
A Review Article on Hyperlipidemia: Types, Treatments and New Drug Targets
| Type | Disorder | Elevated plasma lipoprotein |
|---|---|---|
| IIb | Familial combined hyperlipidemia | LDL and VLDL |
| III | Familial dysbetalipoprotenemia | IDL |
| IV | Familial hypertriglyceridemia | LDL |
| V | Endogenous hypertriglyceridemia | VLDL and chylomicrons |
How are Hyperlipoproteinemia and hyperlipidemia classified?
Hyperlipidemias are also classified according to which types of lipids are elevated, that is hypercholesterolemia, hypertriglyceridemia or both in combined hyperlipidemia….Fredrickson classification of hyperlipidemias.
| Hyperlipo- proteinemia | c |
|---|---|
| OMIM | 118830 |
| Defect | LPL inhibitor in blood |
| Treatment | Diet control |
Which type of Hyperlipoproteinemia is described as having high levels of chylomicrons?
Hyperchylomicronemia is defined by increased concentrations of chylomicrons in plasma caused by a decrease in clearance of the lipoprotein from plasma.
What are examples of triglycerides?
Triglycerides are fats from the food we eat that are carried in the blood. Most of the fats we eat, including butter, margarines, and oils, are in triglyceride form. Excess calories, alcohol or sugar in the body turn into triglycerides and are stored in fat cells throughout the body.
What kind of disease is type II hyperlipoproteinemia?
Type II hyperlipoproteinemia: It is characterized by marked hypercholesterolemia. It includes several genetic diseases, such as familial hypercholesterolemia due to mutation of the gene for the LDL receptor and some diseases that may lead to the elevation of LDL and cholesterol.
What are the signs and symptoms of hyperlipoproteinemia?
Many people with this condition experience no symptoms. They may become aware of it when they develop a heart condition. Other signs and symptoms of hyperlipoproteinemia include: pancreatitis (type 1) abdominal pain (types 1 and 5) enlarged liver or spleen (type 1) lipid deposits or xanthomas (type 1)
How is hyperlipoproteinemia treated in people with diabetes?
Treatment for hyperlipoproteinemia will depend on which type you have. When the condition is the result of hypothyroidism, diabetes, or pancreatitis, treatment will take the underlying disorder into account. Your doctor may prescribe medications like the following to help lower lipid levels:
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