How do you infuse rasburicase?
DOSING AND ADMINISTRATION The first dose of rasburicase should be administered 4 to 24 hours before starting chemotherapy. Rasburicase is given as an intravenous infusion over 30 minutes and should not be given as a bolus infusion (4).
What is rasburicase used to treat?
Rasburicase injection is used to treat high levels of uric acid (a natural substance that builds up in the blood as tumors break down) in people with certain types of cancer who are being treated with chemotherapy medications.
Why is rasburicase not used for gout?
Conclusion: Monthly infusions of rasburicase appear to be a possible therapy for severe gout not treatable by other means. Tolerance of rasburicase in gout appears to be diminished by frequent triggering of gout attacks, and hypersensitivity reactions might be an important limitation to longterm therapy.
Is rasburicase a chemo drug?
Rasburicase is a drug given before and during chemotherapy to treat some types of leukaemia and lymphoma.
Is Rasburicase a chemo drug?
What should my uric acid level be?
Normal Uric acid levels are 2.4-6.0 mg/dL (female) and 3.4-7.0 mg/dL (male). Normal values will vary from laboratory to laboratory. Also important to blood uric acid levels are purines.
Is rasburicase used in gout?
Can you give allopurinol with rasburicase?
Association between rasburicase and allopurinol should be avoided, because the latter may reduce the effect of rasburicase owing to its inhibition of xanthine oxidase and consequent reduced uric acid concentration (Jeha and Pui 2005).
How much rasburicase is in a vial of Elitek?
The drug product is a sterile, white to off-white, lyophilized powder intended for intravenous administration following reconstitution with a diluent. Elitek is supplied in 3 mL and 10 mL colorless, glass vials containing rasburicase at a concentration of 1.5 mg/mL after reconstitution.
What are the side effects of rasburicase injection?
History of the following reactions to rasburicase: anaphylaxis, severe hypersensitivity, hemolysis, methemoglobinemia. ( 4) Glucose-6-phosphate dehydrogenase (G6PD) deficiency. ( 4)
How big is the molecular mass of rasburicase?
Rasburicase is a tetrameric protein with identical subunits. Each subunit is made up of a single 301 amino acid polypeptide chain with a molecular mass of about 34 kDa. The drug product is a sterile, white to off-white, lyophilized powder intended for intravenous administration following reconstitution with a diluent.
How much rasburicase is in one ampule?
NDC 0024-5151-75: One carton contains 1 single-use vial containing 7.5 mg of rasburicase and 1 ampule containing 5 mL diluent. The lyophilized drug product and the diluent for reconstitution should be stored at 2–8°C (36–46°F).