Can TTP cause HUS?
Although most cases of TTP and HUS are idiopathic, several etiologies and associations are well recognized, including infection, drugs, malignancy, chemotherapy, bone marrow transplantation (BMT), and pregnancy (Table 1).
How is MAHA diagnosed?
Microangiopathic hemolytic anemia (MAHA) is a microangiopathic subgroup of hemolytic anemia (loss of red blood cells through destruction) caused by factors in the small blood vessels. It is identified by the finding of anemia and schistocytes on microscopy of the blood film.
What is HUS TTP?
Thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS) are multisystemic disorders that are characterized by thrombocytopenia, microangiopathic hemolytic anemia, and ischemic manifestations, resulting from platelet agglutination in the arterial microvasculature.
What is Maha medical?
Microangiopathic hemolytic anemia (MAHA) — MAHA is a descriptive term for non-immune hemolysis (ie, Coombs-negative hemolysis) resulting from intravascular red blood cell fragmentation that produces schistocytes on the peripheral blood smear (picture 1) [1].
How is HUS TTP diagnosed?
HUS and TTP are characterized by the triad of microangiopathic anemia with red blood cell fragmentation, thrombocytopenia and AKI. TTP has the same three features plus the presence of fever and neurological symptoms, creating a pentad.
What is required for TTP diagnosis?
The diagnosis of TTP requires clinical judgment in addition to measurement of ADAMTS13 activity. Patients with TTP may not seem to be seriously ill; they may have no or only mild neurologic and kidney function abnormalities.
What are the signs and symptoms of TTP?
The signs and symptoms include:
- Purplish bruises on the skin or mucous membranes (such as in the mouth).
- Pinpoint-sized red or purple dots on the skin.
- Paleness or jaundice (a yellowish color of the skin or whites of the eyes).
- Fatigue (feeling very tired and weak).
- Fever.
- A fast heart rate or shortness of breath.