Why is Sodium citrate used in anticoagulation?
Background: Sodium citrate has been used as an anticoagulant to stabilize blood and blood products for over 100 years, presumably by sequestering Ca(++) ions in vitro. Anticoagulation of blood without chelation can be achieved by inhibition of the contact pathway by corn trypsin inhibitor (CTI).
What is the use of Sodium citrate?
CITRIC ACID; SODIUM CITRATE (SIH trik AS id; SOE dee um SIH trayt) makes blood and urine more alkaline or less acidic. This helps prevent some kidney stones. It is also used to treat metabolic acidosis, a condition in some people with kidney problems.
Is Sodium citrate FDA approved?
On July 22, 2021, the FDA issued an Emergency Use Authorization (EUA) for specific sodium citrate tubes for emergency use in health care settings to collect, transport, and store blood specimens for coagulation testing to aid in the identification and treatment of coagulopathy in patients with known or suspected COVID- …
How does Sodium citrate prevent blood from clotting?
Citrate is usually administered as ACD-A, but other forms are available (i.e. ACD-B and trisodium citrate), and it prevents coagulation by binding ionized calcium, which is required in clot formation.
What is anticoagulant sodium citrate?
DESCRIPTION. SODIUM CITRATE 4% W/V ANTICOAGULANT SOLUTION USP is designed to be metered by an apheresis device in apheresis procedures, to prevent platelet activation and coagulation as blood moves throughout the extracorporeal unit (tubing set) in an apheresis procedure.
What is citrate anticoagulant?
Citrate is essentially a regional extracorporeal anticoagulant, with a short systemic half-life of around 5 min, metabolized predominantly by mitochondria in the liver, skeletal muscle and the kidney.
What is anticoagulant used for?
Anticoagulants are medicines that help prevent blood clots. They’re given to people at a high risk of getting clots, to reduce their chances of developing serious conditions such as strokes and heart attacks. A blood clot is a seal created by the blood to stop bleeding from wounds.
How is Sodium citrate used as an anticoagulant?
SODIUM CITRATE 4% W/V ANTICOAGULANT SOLUTION USP is added to tubing sets during apheresis procedures. The solution is connected the tubing set in an apheresis collection. The recommended dose is determined by the apheresis device and metered into the tubing set by the apheresis device.
How does anticoagulant Citrate work?
Method of anticoagulation, advantages and complications. Citrate exerts its anticoagulation effect by chelating ionized calcium, an essential component in the clotting cascade. The target post-filter ionized calcium concentration is usually <0.4 mmol/l [27,28].
What are the different types of anticoagulants?
There are many anticoagulants, including:
- heparin.
- warfarin (Coumadin)
- rivaroxaban (Xarelto)
- dabigatran (Pradaxa)
- apixaban (Eliquis)
- edoxaban (Savaysa)
- enoxaparin (Lovenox)
- fondaparinux (Arixtra)
What is the effect of sodium citrate on blood?
Sodium citrate anticoagulant in blood products binds ionized calcium and in high volume transfusions, especially of fresh frozen plasma, may result in transient hypocalcemia. Metabolism of citrate produces bicarbonate that may result in alkalosis and subsequent hypokalemia.
Is sodium citrate a blood thinner?
This compound uses sodium citrate for its capacity to interfere with thrombosis. It is used when collecting plasma, the liquid in which blood cells are suspended. Sodium citrate helps to keep the blood thin while the plasma is extracted, before the cells and other solid components are returned to the donor.
What is sodium citrate used for in blood?
Citrate, in the form of sodium citrate or acid-citrate-dextrose, is used to disrupt the coagulation cascade and prevent clotting. These citrate compounds bind to the calcium in the blood.
What is the formula for citrate?
The formula of the chemical compound Citric acid is C6H8O7