Is denosumab a antineoplastic drug?
Denosumab is a fully human monoclonal antibody preventing the binding of RANKL to its receptor on osteoclasts’ membrane, and through this mechanism inhibits the resorption of the bone. Furthermore, this agent demonstrates direct anticancer activity through the RANKL signaling pathway.
Which is better denosumab or zoledronic acid?
Conclusions: In patients previously treated with zoledronic acid, denosumab reduces bone turnover more than zoledronic acid, but the increases in LS BMD are comparable. Furthermore, denosumab administration results in reversible inhibition of the metabolically significant endogenous free soluble RANKL levels.
Is Zometa the same as denosumab?
Denosumab, a monoclonal antibody, is given as a subcutaneous injection and works by blocking a protein called RANK ligand, which tells the body to remove bone. Zometa, an intravenous bisphosphonate, uses a slightly different strategy—it attaches directly to the surface of bone to halt bone breakdown.
Is zoledronic acid chemotherapy?
Zoledronic acid (Zometa) is not cancer chemotherapy, and it will not slow or stop the spread of cancer. However, it can be used to treat bone disease in patients who have cancer.
Which problem may occur during therapy with denosumab?
The most common adverse reactions reported with Prolia in patients with postmenopausal osteoporosis are back pain, pain in extremity, musculoskeletal pain, hypercholesterolemia, and cystitis. The most common adverse reactions reported with Prolia in men with osteoporosis are back pain, arthralgia, and nasopharyngitis.
What is denosumab prescribed for?
Denosumab injection (Prolia) is used to treat bone loss in men who are being treated for prostate cancer with certain medications that cause bone loss, to treat bone loss in women with breast cancer who are receiving certain medications that increase their risk for fractures.
What are the side effects of denosumab injection?
Denosumab injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- red, dry, or itchy skin.
- oozing or crusty blisters on skin.
- peeling skin.
- back pain.
- pain in your arms.
- swelling of arms or legs.
- muscle or joint pain.
- nausea.
What are the side effects of zoledronic acid?
More common
- Abdominal or stomach pain.
- back pain.
- bad, unusual, or unpleasant (after) taste.
- bladder pain.
- blistering, crusting, irritation, itching, or reddening of the skin.
- bone pain.
- burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings.
- change in taste.
Is denosumab better than Zometa?
A study has found that Xgeva (chemical name: denosumab), a targeted therapy medicine, is better than Zometa at reducing the risk of a skeletal-related event in women diagnosed with metastatic breast cancer that has spread to the bones. The study also found Xgeva improved quality of life more than Zometa.
What is the difference between Zometa and zoledronic acid?
Reclast and Zometa are two different brands of zoledronic acid. Reclast is used to treat or prevent osteoporosis caused by menopause, or steroid use. This medicine also increases bone mass in men with osteoporosis. Reclast is for use when you have a high risk of bone fracture.