Is sapho syndrome permanent?
Rationale: Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare auto-inflammatory disease with no standardized treatment. Systemic corticosteroids are only transiently effective, but long-term use would bring complications and would not bring long-term remission.
Can sapho syndrome be cured?
There is no specific treatment plan for SAPHO syndrome . It can be a chronic condition but sometimes eventually heals on its own. Joint pain may be managed with nonsteroidal anti-inflammatory drugs and prescription vitamin A is used to treat the acne.
Is sapho syndrome an autoimmune disease?
Background/Purpose: Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare autoimmune disease with heterogeneous presentation and severe disease burden.
Is sapho genetic?
The precise cause of SAPHO syndrome is not known. It is felt that the tendency toward developing SAPHO syndrome can be inherited. Genetic predisposition is suggested by the higher prevalence of HLA-B27, an inherited blood marker, in patients with SAPHO syndrome.
Is SAPHO syndrome rare?
To date, SAPHO syndrome in considered a rare disease, however its prevalence is probably underestimated. Its prevalence is considered not more than 1/10 000. SAPHO syndrome can be seen in all ages, but it is more frequent in children and young to middle-aged adults with a female predominance.
How is SAPHO syndrome diagnosed?
How is the diagnosis made? SAPHO syndrome is suspected when a patient presents with a pustular skin disease in association with rheumatic pain. Magnetic resonance imaging (MRI scan) shows inflammation of the bone marrow or joints at characteristic sites such as the collar bone, breast bone, pelvis, heel, and lower jaw.
Is SAPHO syndrome a disability?
If you or your dependent(s) are diagnosed with Sapho Syndrome and experience any of these symptoms, you may be eligible for disability benefits from the U.S. Social Security Administration.
What causes sapho?
There is currently no known cause of SAPHO syndrome. The findings of a 2019 study suggest that certain genetic factors may play a part in causing SAPHO syndrome. Mutations in genes, called copy number variations, may have a link to SAPHO syndrome.
Is there such a thing as SAPHO syndrome?
Introduction: Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) is an acronym for various osteoarticular and dermatological manifestations that can appear in the same patient. It is a rare syndrome, but since its awareness has increased, there have been more and more such reports in the literature.
What does Sapho stand for in medical terms?
Introduction: Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) is an acronym for various osteoarticular and dermatological manifestations that can appear in the same patient. It is a rare syndrome, but since its awareness has increased, there have been more and more such reports in the literature.
Are there any effective treatment options for Sapho?
There are several treatment options for SAPHO but due to the rarity of the syndrome official therapeutic algorithms do not exist. There are no prospective, controlled studies and all data derive from case series and retrospective studies.
Which is the best anti TNF for Sapho?
Infliximab is the anti-TNF most commonly used in patients with SAPHO. In the majority of cases a dose of 5 mg/kg was used. Massara et al. [8] reported 4 patients treated with infliximab. The first patient was a 47-year-old male with anterior chest wall involvement and PPP.