What does diisopropyl fluorophosphate?
Diisopropyl fluorophosphate (DFP) or Isoflurophate is an oily, colorless liquid with the chemical formula C6H14FO3P. It is used in medicine and as an organophosphorus insecticide….CHEBI:17941.
| Synonyms | Sources |
|---|---|
| Diisopropyl phosphofluoridate | ChemIDplus |
| Diisopropyl phosphorofluoridate | ChemIDplus |
| Diisopropylfluorophosphate | ChemIDplus |
What is the function of diisopropyl fluorophosphate?
Diisopropyl fluorophosphate is a parasympathomimetic drug irreversible anti-cholinesterase and has been used in ophthalmology as a miotic agent in treatment of chronic glaucoma, as a miotic in veterinary medicine, and as an experimental agent in neuroscience because of its acetylcholinesterase inhibitory properties and …
What is affected by diisopropyl fluorophosphate?
Acute exposure to diisopropyl fluorophosphate (DFP) causes irreversible inhibition of acetylcholinesterase activity, leading to various behavioral and autonomic sequelae including hypothermia, reduced motor activity, and other neurological dysfunctions.
Is diisopropyl fluorophosphate a competitive inhibitor?
The substrate may combine with such an enzyme but product formation is inhibited. For example, DFP or di-isopropyl fluorophosphate (nerve gas) reacts with hydroxyl group of serine of acetylcholine-esterase. Inhibition of acetyl choline by DFP is an example of non-competitive irreversible inhibition.
What kind of inhibitor is DFP?
Diisopropylfluorophosphate (DFP), a broad spectrum inhibitor of serine proteases and related enzymes, was the only AChE inhibitor tested that disrupted somitogenesis.
What type of inhibitor is DIPF?
Enzyme Inhibition by Diisopropylphosphofluoridate (DIPF), a Group-Specific Reagent. DIPF can inhibit an enzyme by covalently modifying a crucial serine residue (Section 9.1. 1).
What kind of inhibitor is DIPF?
Enzyme Inhibition
Enzyme Inhibition by Diisopropylphosphofluoridate (DIPF), a Group-Specific Reagent. DIPF can inhibit an enzyme by covalently modifying a crucial serine residue (Section 9.1. 1).
What type of inhibitor is isoleucine?
Threonine deaminase is the first enzyme in the conversion of threonine to isoleucine. Isoleucine inhibits threonine deaminase through feedback inhibition. Feedback inhibition is a normal biochemical process that makes use of noncompetitive inhibitors to control some enzymatic activity.
What kind of inhibitor is DIFP?
Irreversible Inhibition: Poisons The nerve gases, especially Diisopropyl fluorophosphate (DIFP), irreversibly inhibit biological systems by forming an enzyme-inhibitor complex with a specific OH group of serine situated at the active sites of certain enzymes.
Is Isoflurophate reversible?
Isoflurophate damages the acetylcholinesterase enzyme and is therefore irreversible, however, pralidoxime can displace organophosphates such as isoflurophate from acetylcholinesterase, but only if administered before isoflurophate damages (alkylates) the enzyme.
What is the chemical formula of diisopropyl fluorophosphate?
Diisopropyl fluorophosphate is an oily, colorless liquid with the chemical formula C 6 H 14 FO 3 P. It is used in medicine and as an organophosphorus insecticide[citation needed]. It is stable, but undergoes hydrolysis when subjected to moisture, producing hydrofluoric acid .
Where does diisopropyl fluorophosphate combine with serine?
It combines with the amino acid serine at the active site of the enzyme acetylcholinesterase, an enzyme that deactivates the neurotransmitter acetylcholine. Neurotransmitters are needed to continue the passage of nerve impulses from one neuron to another across the synapse.
What kind of liquid is isofluorphate used for?
Isofluorphate appears as oily liquid. Clear, colorless or faintly yellow liquid. This material is used as a research tool in neuroscience for its ability to inhibit cholinesterase (by phosphorylation) on an acute/sub-acute basis and to produce a delayed neuropathy. An insecticide. Used in Germany as a basis for “nerve gases”. (EPA, 1998)