What is the difference between dantrolene and RYANODEX?
Low-concentration high-volume dantrolene sodium products contain 3000 mg of mannitol per 20-mg dantrolene sodium vial, whereas RYANODEX® contains just 125 mg of mannitol per 250-mg vial. 16-18 Of course, the difference is much larger when considering the number of vials needed to treat a patient.
What is the generic name for Dantrium?
GENERIC NAME: DANTROLENE – ORAL (DAN-trow-leen)
How much does RYANODEX cost?
The cost for Ryanodex intravenous powder for injection 250 mg is around $2,954 for a supply of 1 powder for injection, depending on the pharmacy you visit….Intravenous Powder For Injection.
| Quantity | Per unit | Price |
|---|---|---|
| 1 | $2,953.61 | $2,953.61 |
Who makes RYANODEX?
The drug manufacturer Eagle Pharma- ceuticals, Inc. is promoting Ryanodex as the first significant enhancement to MH treatment options in more than three decades.
What do you mix with RYANODEX?
How do we reconstitute RYANODEX®? RYANODEX® (dantrolene sodium) for injectable suspension should be reconstituted with 5 mL sterile water for injection (without a bacteriostatic agent).
What is RYANODEX used for?
Ryanodex (dantrolene sodium) is a skeletal muscle relaxant used to treat malignant hyperthermia in conjunction with appropriate supportive measures, and to prevent malignant hyperthermia in patients at high risk.
What is Dantrium used for?
This medication is used to treat muscle tightness and cramping (spasms) caused by certain nerve disorders such as spinal cord injury, stroke, cerebral palsy, and multiple sclerosis. It works by relaxing the muscles.
What is methocarbamol good for?
Methocarbamol is a muscle relaxer that is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury. Methocarbamol injection is sometimes used in the treatment of tetanus, (lockjaw) which causes painful tightening of the muscles.
How do you administer Ryanodex?
Administering RYANODEX® Administer RYANODEX® by intravenous push at a minimum dose of 1 mg/kg. If the physiologic and metabolic abnormalities of MH continue, administer additional intravenous boluses up to the maximum cumulative dosage of 10 mg/kg.
Does Ryanodex contain mannitol?
Each vial of RYANODEX® (dantrolene sodium) for injectable suspension contains only 125 mg of mannitol (the amount of mannitol in RYANODEX® is insufficient to maintain diuresis) compared with 3000 mg of mannitol in each vial of other dantrolene sodium for injection products.
Who makes Dantrium?
The only other company that I know of who makes dantrolene is a Brazilian company, Cristalia. This past month P&G announced the sale of its product to two companies, JHP Pharma and SPE Pharm. The former acquired the rights to North America, the latter to Europe, Chile and certain other countries.
Does RYANODEX contain mannitol?
How much dantrolene is in one vial of ryanodex?
One vial of RYANODEX® contains the same amount of dantrolene sodium as 12.5 vials of other approved formulations 5-7 Each vial of RYANODEX® contains 250 mg of dantrolene sodium and requires reconstitution with only 5 mL of sterile water for injection vs 60 mL per vial with other formulations1,5-7
How long does it take to take 2.5 mg of ryanodex?
Time to administer 2.5 mg/kg loading dose of RYANODEX® for a 100 kg patient is 1 minute compared to >22 minutes for other approved formulations 1,4 * RYANODEX® requires fewer vials (depending on the patient) and less sterile water for injection volume compared to other dantrolene formulations 5-7
How long does it take to reconstitute ryanodex with sterile water?
Advanced nanosuspension technology is combined with a lyophilized formulation that allows RYANODEX® to be reconstituted with sterile water for injection and administered in significantly less time compared with other formulations of dantrolene sodium 1,4 Simplified and rapid reconstitution to prepare a single vial within 10 seconds 1,4
How is ryanodex used in the treatment of hyperthermia?
RYANODEX® (dantrolene sodium) for injectable suspension is indicated for the treatment of malignant hyperthermia in conjunction with appropriate supportive measures, and for the prevention of malignant hyperthermia in patients at high risk.