What is doxorubicin hydrochloride used for?
Doxorubicin is used in combination with other medications to treat certain types of bladder, breast, lung, stomach, and ovarian cancer; Hodgkin’s lymphoma (Hodgkin’s disease) and non-Hodgkin’s lymphoma (cancer that begins in the cells of the immune system); and certain types of leukemia (cancer of the white blood cells …
Is doxorubicin cytotoxic or cytostatic?
The cytostatic drug doxorubicin is a well-known chemotherapeutic agent which is used in treatment of a wide variety of cancers.
What is the IC50 of cisplatin?
The mean IC50 of the 10 samples treated with cisplatin and carboplatin was 2.0 and 22.4 mg/ml, respectively, which again demonstrated a 10- fold difference in antileukemic activity between the two plati- num derivatives.
What is the IC50 of paclitaxel?
The fraction of surviving cells fell sharply after exposure for 24 h to paclitaxel concentrations ranging from 2 to 20 nM; the paclitaxel IC50 was found to range between 2.5 and 7.5 nM.
How does doxorubicin hydrochloride work?
How doxorubicin works. Doxorubicin is a type of chemotherapy drug called an anthracycline. It slows or stops the growth of cancer cells by blocking an enzyme called topo isomerase 2. Cancer cells need this enzyme to divide and grow.
What is the IC50 value of doxorubicin for PC3?
The IC50s of DOX were 908 nM and 343 nM for PC3 and DU145, respectively. Strong synergy was seen when PC3 was treated with DOC at concentrations lower than its IC50 values (0.125 ~ 0.5 nM) plus DOX (2 ~ 8 times IC50).
How is doxorubicin used to treat hepatocellular carcinoma?
Doxorubicin induces GFP-LC3 puncta formation in hepatocellular carcinoma cells. SK-Hep1 cells were treated with doxorubicin (2.5 μM) or CQ (10 μM) plus doxorubicin for 7 h and cells were examined with a confocal microscope for GFP-LC3 punctuation/aggregation.
What is the molecular weight of doxorubicin HCl?
Licensed by Pfizer Catalog No.S1208 Synonyms: NSC 123127. Molecular Weight(MW): 579.98. Doxorubicin (Adriamycin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.
How is doxorubicin used in the treatment of HIV?
Doxorubicin is used in the concomitant treatment of HIV-infected patients but is found to be at high risk of HBV reactivation. Doxorubicin (Adriamycin, NSC 123127, DOX, Hydroxydaunorubicin) HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage, mitophagy and apoptosis in tumor cells.