What is differentiated vulvar intraepithelial neoplasia?

What is differentiated vulvar intraepithelial neoplasia?

Differentiated-type vulvar intraepithelial neoplasia (dVIN) is a non-human papilloma virus (HPV)-related precursor lesion to vulvar squamous carcinoma. The terminology has only become recognized clinically and histopathologically in recent years despite being described more than 50 years ago.

Is VIN serious?

Differentiated VIN has a higher risk of developing into a cancer than high grade squamous intraepithelial lesion (HSIL). So surgery is usually the best treatment for this type of VIN.

How long does it take for VIN to become cancer?

Vulval intraepithelial neoplasia (VIN) is a precancerous condition. This means there are changes to certain cells in the vulva that are not cancerous, but could potentially turn into cancer at a later date. This is a gradual process that usually takes well over 10 years.

What is vulvar intraepithelial neoplasia?

Vulvar intraepithelial neoplasia, also known as VIN, is a non-invasive squamous lesion and precursor of squamous cell carcinoma (SCC) of the vulva. There is no screening test for vulvar intraepithelial neoplasia. Diagnosis of VIN is made clinically and confirmed with a biopsy.

Does VIN 3 come back?

Women who have been treated for VIN have a risk that it will come back (recur). You will have regular follow-up visits, usually every few months. These visits will happen less often if there are no problems. Report any concerns and signs or symptoms to the doctor without waiting for your next scheduled visit.

What is VIN caused by?

The exact cause is not known, however it has been linked to: Human papillomavirus (HPV), a common infection. Herpes simplex virus. Granuloma inguinale, a sexually transmitted disease (STD)

Is vulvar intraepithelial neoplasia curable?

When occult invasion is not a concern, vulvar HSIL (VIN usual type) can be treated with excision, laser ablation, or topical imiquimod (off-label use). Women with vulvar HSIL (VIN usual type) are at risk of recurrent disease and vulvar cancer throughout their lifetimes.

Can VIN go away on its own?

Does it need to be treated? If left untreated, in a small number of cases VIN may go away by itself. However, most cases of VIN do not and because of the risk that it may turn into cancer — treatment is usually advised.

What are the subtypes of HPV with altered differentiation?

Accessed September 11th, 2021. Subtypes: differentiated exophytic vulvar intraepithelial lesion (DEVIL) and vulvar acanthosis with altered differentiation (VAAD) with currently unknown prognosis but potential to develop carcinoma Currently, there are no reliable immunohistochemical or molecular markers to establish the diagnosis

Is there a difference between LSIL and Vin 2 neoplasia?

High grade squamous intraepithelial lesion (VIN usual type) (HSIL), previously called VIN 2 and VIN3 Intraepithelial neoplasia, differentiated-type (dVIN) HSIL and dVIN have potential to progress to invasive vulval cancer, whereas LSIL lesions are low risk and are not neoplastic. HSIL-associated cancers tend to be warty in appearance.

What causes low grade Squamous Intraepithelial Lesion ( LSIL )?

But the risk is low. VIN 1 is now called low grade squamous intraepithelial lesion (LSIL). LSIL is generally a mild abnormality. It is usually caused by low risk types of the human papilloma virus (HPV). These low risk types can cause warts in this area.

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