What is Nephronophthisis?
Nephronophthisis is a disorder that affects the kidneys. It is characterized by inflammation and scarring (fibrosis) that impairs kidney function . These abnormalities lead to increased urine production (polyuria), excessive thirst (polydipsia), general weakness, and extreme tiredness (fatigue).
What is Nphp?
Nephronophthisis (NPHP) represents an autosomal recessive cystic kidney disease and is one of the most common genetic disorders causing end-stage renal disease (ESRD) in children and adolescents. NPHP is a genetically heterogenous disorder with twenty identified genes.
Is Nephronophthisis a genetic disorder?
Nephronophthisis is a genetic disorder of the kidneys which affects children. It is classified as a medullary cystic kidney disease. The disorder is inherited in an autosomal recessive fashion and, although rare, is the most common genetic cause of childhood kidney failure. It is a form of ciliopathy.
When was Nephronophthisis discovered?
Nephronophthisis (NPH), an autosomal recessive disorder initially described in 1945 by Smith and Graham and in 1951 by Fanconi, is a chronic tubulointerstitial nephritis that uniformly progresses to end-stage renal disease (ESRD) [1, 2].
Can overseas Pakistani get Naya Pakistan Housing Scheme?
4 Can Overseas Pakistanis avail House Loan Facility under NPHP? Loan facility is available for all Pakistani nationals living in country or outside the country with satisfactory credit history.
How is nephropathy diagnosed?
Screening for microalbuminuria with a spot urine albumin/creatinine ratio identifies the early stages of nephropathy. Positive results on two of three tests (30 to 300 mg of albumin per g of creatinine) in a six-month period meet the diagnostic criteria for diabetic nephropathy.
What is the difference between nephropathy and CKD?
Q: What is the difference between “Chronic Kidney Disease” and “diabetic nephropathy”? A: Diabetic nephropathy refers generally to the damage to the kidneys caused by diabetes. Chronic Kidney Disease (CKD) has a specific clinical definition (see below) and may be caused by diabetes or by other diseases.
What is acquired renal cystic disease?
Acquired cystic kidney disease happens when a person’s kidneys develop fluid-filled sacs, called cysts, over time. Acquired cystic kidney disease is not the same as polycystic kidney disease (PKD), another disease that causes the kidneys to develop multiple cysts.