What is solubilization in chemistry?
Solubilization is the action of certain chemical reagents on organic materials (such as animal or plant tissue) that effects a structural breakdown (or digestion) into a liquid form that can then be directly dissolved in a liquid scintillation cocktail.
What do you mean by micellar solubilization?
Micellar solubilization (solubilization) is the process of incorporating the solubilizate (the component that undergoes solublization) into or onto micelles. Solublization may occur in a system consisting of a solvent, an association colloid (a colloid that forms micelles), and at least one other solubilizate.
What is solubilization process?
The process of solubilization involves the breaking of intermolecular or inter-ionic bonds in the solute, the separation of the molecules of the solvent to provide space in the solvent for the solute, interaction between the solvent and the solute molecule or ion (Fig. 1) (Gennaro, 2005).
Which agent is used in micellar solubilization?
The drug paclitaxel is highly lipophilic in nature and insoluble in water. Its current marketed form as an intravenous infusion paclitaxel is solubilized by using Cremophor EL, which is a nonionic surfactant and helps in the micellar solubilization.
What is solubilization Slideshare?
SOLUBILIZATION It can be defined as the preparation of a thermodynamically stable isotropic solution of a substance normally insoluble or very slightly soluble in a given solvent by the addition of component or components or by any suitable methods.
What is solubility and solubilization?
1. Phenomenon of Solubilization. Broadly, solubility can be stated as a process to generate a homogenous system maintained by achieving dynamic equilibrium between the simultaneous and opposite methods of dissolution and phase joining (e.g., precipitation of solids) (Myrdal and Yalkowsky, 2002, Savjani et al., 2012).
What is the importance of solubilization in pharmacy?
Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response.
What is solubilization in physical pharmacy?
SOLUBILITY: DEFINITION: The maximum amount of solute that can be dissolve in a given amount of solvent. FACTORS THAT EFFECT SOLUBILIZATION: ◦ NATURE OF SOLUTE AND SOLVENT: ◦ The amount of solute that dissolves depends on what type of solute it is.
What is the importance of solubilization in pharmaceutics?
Why is solubility important for life?
Solubility is important to life since biomolecules of life must move from one place to another in order for metabolic functions to occur.
What are the applications of solubility?
Applications of Solubility Product
- (i) In predicting the formation of a precipitate.
- Case I: When , then solution is unsaturated in which more solute can be dissolved.
- Case II: When , then solution is saturated in which no more solute can be dissolved but no ppt. is fomed.
What are Solubilising agents?
Abstract. The use of solubilizing agents to improve the solubility of poorly water-soluble drugs often results in an alteration of intestinal membrane barrier function and intestinal membrane damage.
How is Micellar solubilization used in aqueous environments?
Micellar solubilization is a powerful alternative for dissolving hydrophobic drugs in aqueous environments. In this work, we provide an insight into this subject. A concise review of surfactants and micelles applications in pharmacy was carried out. Initially, a description of surfactants and aqueous micellar systems is presented.
What are the side effects of micellar solubilization?
LDL reduction is typically 15% to 20% with these agents. Gastrointestinal side effects such as constipation, bloating, heartburn, and nausea are the major drawbacks to the use of the bulk agents.
How does Micellar solubilization affect the photolysis of herbicide?
Surfactants may enhance herbicide photolysis due to micellar solubilization of the herbicide and/or photosensitization if the surfactant contains a chromophore, which absorbs in the near UV wavelengths >290 nm.
How is the size of a micelle controlled?
Micelle sha pe and size can be controll ed strength and pH. In partic ular, depending on the sur- dal micelles. Micelle growth is c ontrolled primaril y by (18, 22). it. In ionic mice lles, the in terfacial region between the counter ions associated with the micelle, and water.