What does the Ki-67 marker detect or measure?

What does the Ki-67 marker detect or measure?

Ki-67: Ki-67 is a protein in cells that increases as they prepare to divide into new cells. A staining process can measure the percentage of tumor cells that are positive for Ki-67. The more positive cells there are, the more quickly they are dividing and forming new cells.

What is Ki-67 proliferation index?

The Ki67, a marker of cell proliferation, is a non-histone nuclear protein expressed throughout the active phase of cell cycle, except G0 and early G1. This proliferative marker has become an important and reliable predictive and prognostic marker in BC patients (Scholzen and Gerdes, 2000; Esteva and Hortobagyi, 2004).

Is Ki-67 the same as Oncotype?

Background: Ki-67 is a marker of proliferating cells. The recurrence score based on the 21-gene breast cancer assay also called Oncotype Dx provides prognostic and predictive information for recurrence in early stage breast cancer patients.

How is Ki-67 used as a proliferation marker?

Ki-67 protein has been widely used as a proliferation marker for human tumor cells for decades. In recent studies, multiple molecular functions of this large protein have become better understood.

Which is a cellular marker for cell proliferation?

The Ki-67 protein (MKI67) is a cellular marker for cell proliferation (Figure 3). Ki67 is present during all active phases of the cell cycle (G1, S, G2, and M) but is absent in resting cells (G0). The nuclear expression of Ki67 can be evaluated to assess tumor proliferation by IHC (Figure 4).

When does Ki67 occur in the cell cycle?

Ki67 is present during all active phases of the cell cycle (G1, S, G2, and M) but is absent in resting cells (G0). The nuclear expression of Ki67 can be evaluated to assess tumor proliferation by IHC (Figure 4). Ki67 is a popular proliferation marker and is routinely used in pathology labs due to its diagnostic and prognostic power in cancer.

What is the function of the Ki-67 protein?

Although the Ki-67 protein is well characterized on the molecular level and extensively used as a proliferation marker, the functional significance still remains unclear. There are indications, however, that Ki-67 protein expression is an absolute requirement for progression through the cell-division cycle.