What causes RS3PE syndrome?
Although the cause of RS3PE is unknown, the following may contribute to the disease: Elevated levels of vascular endothelial growth factor and matrix metalloproteinase 3. Paraneoplastic syndrome. HLA-B7, HLA-CW7, and HLA-DQW.
What is RS3PE syndrome?
Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome is characterized by symmetrical synovitis and swelling of both the upper and lower extremities. The anatomical determinant of RS3PE is predominantly extensor tenosynovitis as revealed by magnetic resonance imaging (MRI).
Is RS3PE an autoimmune disease?
Although RS3PE is known to be a disease of the elderly population, it is also seen in young age groups, but it is extremely rare. Systemic vasculitis, autoimmune diseases, and malignancy accompany in 30% of RS3PE patients [9,10].
What is Remitting seronegative symmetrical synovitis with pitting edema?
Remitting seronegative symmetrical synovitis with pitting edema is a disease/syndrome characterized by an acute onset of polyarthritis with pitting edema, negative rheumatoid factor, absence of joint erosions on radiographs, synovitis suggested by USG/MRI, and an exquisite response to low-dose steroids, with a …
How do you treat RS3PE?
Classic RS3PE responds well with low dose corticosteroids (10-15mg) with sustained and maintained remission within 6-18 months. NSAIDs and in some cases hydroxychloroquine have also proven to be effective.
Is palindromic rheumatism curable?
There is no cure for palindromic rheumatism at the moment, but certain treatments and lifestyle changes can improve people’s symptoms, reduce the severity of attacks, and improve quality of life.
What is sero negative RA?
If you’re seronegative for rheumatoid arthritis (RA), you may or may not have RA. It can make it harder to get an RA diagnosis. Being seronegative for RA means that a blood test doesn’t find certain antibodies your body typically makes when you have the condition.
What is seronegative arthropathy?
Seronegative spondyloarthropathies are a family of joint disorders that classically include ankylosing spondylitis (AS), psoriatic arthritis (PsA), inflammatory bowel disease (IBD) associated arthritis, reactive arthritis (formerly Reiter syndrome; ReA), and undifferentiated SpA.
Which joint is spared in rheumatoid arthritis?
The most commonly involved hand joints in RA are the MCP and PIP joints. The DIP joints are usually spared.
What is symmetric edema?
Remitting seronegative symmetrical synovitis with pitting edema (or sometimes RS3PE) is a rare syndrome identified by symmetric polyarthritis, synovitis, acute pitting edema (swelling) of the back of the hands and/or feet, and a negative serum rheumatoid factor.
Can Rheumatoid arthritis cause pitting edema?
Distal extremity swelling with pitting oedema due to altered lymphatic drainage has been reported in some patients with rheumatoid arthritis (RA). The resistant-to-therapy oedema usually affected the upper limbs in an asymmetrical pattern.
What kind of synovitis is RS3PE syndrome?
Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE), first described in 1985 by McCarty et al, is a rare syndrome that is a subset of the seronegative symmetrical polyarthritis of older people. 1.
What does RS3PE stand for in medical terms?
Remitting, seronegative, symmetric synovitis with pitting edema (RS3PE) is a syndrome with an acute onset, benign course characterized by rheumatoid factor seronegativity, edema on the dorsum of the hands and feet, symmetric distal synovitis, and flexor tendinitis on the fingers.
What are the diagnostic criteria for RS3PE syndrome?
The patient was thus diagnosed with RS3PE syndrome, for which he satisfied all four diagnostic criteria: 1) pitting edema in the limbs, 2) acute onset, 3) age ≥ 50 years, and 4) rheumatoid factor negativity. He was treated with oral prednisolone, resulting in the normalization of his serum VEGF level to 34.5 pg/mL 1 month after starting treatment.
Which is a paraneoplastic form of RS3PE syndrome?
Of interest are paraneoplastic forms of RS3PE as primary or secondary manifestations of a neoplastic process without response to corticosteroids.