How does spironolactone act as a diuretic?

How does spironolactone act as a diuretic?

Potassium-Retaining Diuretics (e.g., Spironolactone, Amiloride, Eplerenone) Spironolactone is an aldosterone receptor antagonist that acts in the renal distal tubule and collecting ducts, decreasing the reabsorption of sodium and water and decreasing the excretion of potassium.

What enzyme does spironolactone inhibit?

Spironolactone has been reported to induce the enzymes CYP3A4 and certain UDP-glucuronosyltransferases (UGTs), which can result in interactions with various medications. However, it has also been reported that metabolites of spironolactone irreversibly inhibit CYP3A4.

What receptor does spironolactone block?

Spironolactone is a powerful potassium-sparing diuretic that inhibits the binding of aldosterone to mineralocorticoid receptors in many tissues, including epithelial cells of the distal convoluted tubule and collecting duct.

How does spironolactone inhibit aldosterone?

Spironolactone and eplerenone competitively antagonize aldosterone by binding to its receptor on the late distal tubule and the collecting duct to increase sodium, calcium, and water excretion and decrease potassium loss.

Does spironolactone make pee?

Aldactone (spironolactone) is a potassium-sparing diuretic (water pill) that makes you urinate more without lowering the amount of potassium in your body. It works in your kidneys to remove extra water and sodium, which helps lower the amount of fluid in your blood vessels and other areas of your body.

What kind of diuretic is spironolactone?

Spironolactone is a potassium-sparing diuretic that also prevents your body from absorbing too much salt and keeps your potassium levels from getting too low.

Does spironolactone inhibit cortisol?

Glucocorticoid activity Most studies have found that spironolactone has no effect on cortisol levels. However, some studies have observed increased cortisol levels with spironolactone treatment. Spironolactone notably does not decrease cortisol or aldosterone levels.

Is spironolactone an aldosterone antagonist and a potassium-sparing diuretic?

Aldosterone antagonists (spironolactone, eplerenone) also known as “potassium sparing diuretics” block the action of aldosterone inhibiting the reuptake of sodium and water.

Why does spironolactone make you pee?

Is spironolactone a good diuretic?

For a really cheap and safe medication, spironolactone has many uses. From heart health to hair growth, this popular diuretic is safe and effective.

Why is spironolactone considered hazardous?

The drug causes loss of libido, menstrual irregularity, and breast pain. It has been linked with breast cysts, and possibly breast cancer. By interfering with your hypothalamic-pituitary-adrenal (HPA) axis, spironolactone causes low blood pressure, headaches, fatigue, and depression. It increases the risk of blood clots.

What are the side effects of spironolactone?

Common spironolactone side effects may include: mild nausea or vomiting, diarrhea; breast swelling or tenderness; dizziness, headache, mild drowsiness; leg cramps; or. impotence, difficulty having an erection.

When not to use spironolactone?

You should not use spironolactone if you are allergic to it, or if you have: Addison’s disease (an adrenal gland disorder); high levels of potassium in your blood (hyperkalemia); if you are unable to urinate; or if you are also taking eplerenone.

When to take spironolactone morning or night?

Spironolactone should be taken at the same time (s) each day to maintain an even level of the medicine in your blood. Because spironolactone increases urination, it is best to take it in the morning (to avoid needing to get up to use the bathroom throughout the night).

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