What is the function of 9-cis-retinoic acid?
Metabolic conversion of vitamin A (retinol) into retinoic acid (RA) controls numerous physiological processes. 9-cis-retinoic acid (9cRA), an active metabolite of vitamin A, is a high affinity ligand for retinoid X receptor (RXR) and also activates retinoic acid receptor (RAR).
What is retinoic acid used to treat?
What is retinoic acid? Retinoic acids, or retinoids, such as isotretinoin and tretinoin are related to Vitamin A. They may be used to treat severe types of acne, and to help treat certain types of cancer such as leukemia or neuroblastoma.
Is isotretinoin retinoic acid?
Isotretinoin, also known as 13-cis-retinoic acid and sold under the brand name Accutane among others, is a medication primarily used to treat severe acne. It is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers.
What is retinoic acid response element?
The retinoic acid receptors are transcription factors which bind as RAR-RXR heterodimers to particular sequences, the retinoic acid response elements (RAREs) in the regulatory region of specific target genes (Figure 1).
Is retinol the same as retinoic acid?
Retinol is not retinoic acid—retinol works because it converts to retinoic acid. But there are also various types of esters, also derivatives of vitamin A, that are often described as retinol: Retinyl Acetate, Retinyl Linoleate, Retinyl Palmitate and Retinyl Proprionate.
Is isotretinoin 10mg safe?
Isotretinoin is recommended for patients with moderate acne that produces scarring or distress, or for acne that persists following other treatments. Low-dose isotretinoin, e.g. 10 mg per day, is effective for most patients.
How do you take isotretinoin 10mg?
Swallow capsules whole. Do not crush or chew them. Isotretinoin is usually taken twice daily for 15-20 weeks, or as directed by your doctor. Directions for most generic forms of isotretinoin state that it should be taken with meals.
What do retinoid receptors do?
Retinoid receptors are nuclear receptors (a class of proteins) that bind to retinoids. When bound to a retinoid, they act as transcription factors, altering the expression of genes with corresponding response elements.
What is retinoic acid cream?
Tretinoin is a medication used to treat acne and sun-damaged skin. It can’t erase deep wrinkles, but it can help improve the appearance of surface wrinkles, fine lines, and darks spots. Tretinoin is also known as retinoic acid.
Is retinoic acid good for skin?
Retinol exfoliates the skin, increases skin cell turnover, and stimulates collagen synthesis. It is considered the gold standard for its anti-aging and skin clearing benefits. It is available in the forms of oils, creams, and serum.
Is adapalene Retin A?
Retin-A (tretinoin) Cream and Gel and Differin (adapalene) are retinoids (a form of vitamin A) used for the topical treatment of acne vulgaris.
What is the role of 9-cis-retinoic acid?
9-cis-retinoic acid is a retinoic acid in which the exocyclic double bonds have 7E,9Z,11E,13E geometry. It has a role as an antineoplastic agent, a retinoid X receptor agonist, a metabolite and a keratolytic drug.
What kind of retinoid is alitretinoin used for?
From Wikipedia, the free encyclopedia Alitretinoin, or 9-cis-retinoic acid, is a form of vitamin A. It is also used in medicine as an antineoplastic (anti-cancer) agent developed by Ligand Pharmaceuticals. It is a first generation retinoid.
Which is retinoic acid has anti-teratogenic activity?
Alitretinoin is an orally- and topically-active naturally-occurring retinoic acid with antineoplastic, chemopreventive, teratogenic, and embryotoxic activities.