What is a J mice?
The A/J strain is an inbred albino strain of mouse model. It is very frequently used in cancer research, on account of its strong tendency to develop tumors when presented with common carcinogens. It is one of the most popular strains used in mouse experiments.
Are B6 mice CD45 2?
2 B6 strain is the CD45 isoform. Journal Article: Jang et al., 2018. Cutting Edge: Check Your Mice−−A Point Mutation in the Ncr1 Locus Identified in CD45. 1 Congenic Mice with Consequences in Mouse Susceptibility to Infection.
What is the strain of mice?
C57BL/6 and BALB/c are the main mouse strains. Sprague-Dawley and Wistar are the main rat strains. The Jackson Laboratory, Charles River Laboratories, Taconic Biosciences, and Harlan Laboratories are the main suppliers. Major research applications are in immunology, oncology, physiology, pathology, and neuroscience.
What is an inbred strain of mice?
Inbred mouse strains are defined as colonies produced by a minimum of 20 generations of brother-sister mating, traceable to a single founding pair.
What are SJL mice?
SJL mice display a very high incidence of reticulum cell sarcomas resembling Hodgkin’s disease by approximately one year of age. This strain is also characterized by extreme aggression in males and its susceptibility to experimental autoimmune encephalomyelitis (EAE) for multiple sclerosis research.
Are B6 mice CD45 1 or CD45 2?
Two isoforms have been identified in mice: the common form is CD45. 2, which is expressed by the C57BL/6 (B6) strain and is encoded by the Ptprcb allele; and an additional allelic variant Ptprca which encodes the CD45. 1 isoform, was identified in the SJL mouse strain.
What is transgenic mouse strain?
Transgenic mice are mouse models that have had their genomes altered for the purpose of studying gene functions.
Why use Swiss Webster mice?
Also Known As:SW, Swiss Inbred SWR/J mice are used widely in research as a general purpose strain. Aging mice exhibit a high incidence of lung and mammary gland tumors. They also develop extreme polydipsia and polyuria (nephrogenic diabetes insipidus) with increasing age.
What is CD45 1 a marker for?
Allelic variants of the pan-haematopoietic cell marker CD45, identified as CD45. 1 and CD45. 2, have been established as a marker system to track haematopoietic cells following congenic mouse bone marrow transplants.
Why are SJL / J mice better than BALB / c mice?
SJL/J mice have also been shown to have an increased rate of muscle regeneration after injury when compared to BALB/c mice. Due to a mutation in Ceacam1 SJL/J mice are resistant to infection by certain strains of mouse hepatitis virus MHV-4.
What kind of disease does SJL mouse have?
Detailed Description. SJL mice display a very high incidence of reticulum cell sarcomas resembling Hodgkin’s disease by approximately one year of age. Sarcomas first appear in the Peyer’s patches and mesenteric lymph nodes and later in the spleen, liver, thymus and other lymph nodes.
What kind of mouse is b6sjlf1 / J produced by?
Produced by a cross between a C57BL/6J (B6) female x an SJL/J (SJL) male. B6SJLF1/J mice are heterozygous for B6 and SJL alleles at all loci in their genome. This strain is often used in the production of transgenic mice. Read More +.
Why are SJL / J mice good models for muscular dystrophy?
Detailed Description. SJL/J mice develop a spontaneous myopathy resulting from a splice-site mutation in the Dysferlin gene. This Dysfim allele has been shown to result in decreased levels of dysferlin protein in SJL/J mice and makes this strain a good model for limb girdle muscular dystrophy 2B.