What is SOX2 marker?
SOX2, a persistent marker for multipotential neural stem cells derived from embryonic stem cells, the embryo or the adult. Dev Neurosci.
Is SOX2 a protein?
Sox2 is a member of the Sox family of transcription factors, which have been shown to play key roles in many stages of mammalian development. This protein family shares highly conserved DNA binding domains known as HMG (High-mobility group) box domains containing approximately 80 amino acids.
What does the SOX2 gene do?
The SOX2 gene provides instructions for making a protein that plays a critical role in the formation of many different tissues and organs during embryonic development. The SOX2 protein is especially important for the development of the eyes.
What activates SOX2?
In melanoma cells, epidermal growth factor receptor (EGFR) activation enhances STAT3 nuclear translocation and binding to the SOX2 promoter, leading to increased SOX2 expression to facilitate cell survival and self-renewal.
How is SOX2 regulated?
Expression and function of SOX2 is regulated through several post-translational modifications such as ubiquitination, sumoylation, phosphorylation, methylation and acetylation.
Is SOX2 a cell reprogramming factor?
We conclude that Sox2 plays a crucial role in a dose-dependent manner in direct reprogramming of somatic cells to iPSCs.
What is the known function of the SOX2 gene in mammals?
How is Sox2 related to the development of cancer?
SOX2 has been shown to be associated with numerous cancer types, even described in some cases as an oncogene, and controls cancer cell physiology via promoting oncogenic signaling and maintaining cancer stem cells.
What is the role of Sox2 in CSCs?
Sox2 is known as the undifferentiated cell marker. Recent studies have shown that Sox2 may also be involved in the maintenance of cancer stem cells (CSCs) in skin and bladder cancers. In this study, we aimed to clarify the role of Sox2 in colorectal CSCs.
What is the role of Sox2 in stem cells?
SOX2 has been described as an essential embryonic stem cell gene and moreover, a necessary factor for induced cellular reprogramming. SOX2 research has only recently switched focus from embryogenesis and development to SOX2’s function in disease.
When does Sox2 become restricted to certain cell populations?
While SOX2 is homogeneously expressed in the inner cell mass, it becomes restricted to certain cell populations when the embryo undergoes the transformation from a single-layered to a multi-layered structure during gastrulation.