What is an example of a protease inhibitor?
Examples of protease inhibitors include ritonavir, saquinavir, and indinavir. Single-agent therapy with a protease inhibitor can result in the selection of drug-resistant HIV.
What drugs are protease inhibitors?
Protease inhibitor drugs
- atazanavir (Reyataz)
- darunavir (Prezista)
- fosamprenavir (Lexiva)
- indinavir (Crixivan)
- lopinavir/ritonavir (Kaletra)
- nelfinavir (Viracept)
- ritonavir (Norvir)
- saquinavir (Invirase)
What was the first protease inhibitor?
The first protease inhibitor to be approved by the US Food and Drug Administration (FDA) was saquinavir, in December 1995, a mere 97 days after the FDA received its marketing application. Within months, two other protease inhibitors, ritonavir and indinavir, were also approved.
Which is a protease inhibitor quizlet?
Protease inhibitors prevent viral replication by selectively binding to viral proteases (e.g. HIV-1 protease) and blocking proteolytic cleavage of protein precursors that are necessary for the production of infectious viral particles.
What foods have protease inhibitors?
Protease inhibitors have been found in a great variety of plants, including most legumes and cereals and certain fruits (apples, bananas, pineapples and raisins) and veget- ables (cabbage, cucumbers, potatoes, spinach and to- matoes) (4,43).
What are protease inhibitors in food?
Hence, plant protease inhibitors (PPIs) fit the definition of a functional food. Many researchers have classified these plant protease inhibitors into families such as Bowman-Birk, Kunitz, Potato I, Potato II, Serpine, Cereal, Rapeseed, Mustard, and Squash (Laskowski and Qasim, 2000; De Leo et al., 2002).
Is Abacavir a protease inhibitor?
Protease inhibitors such as tipranavir or ritonovir may decrease the serum concentration of abacavir through induction of glucuronidation. Abacavir is metabolized by both alcohol dehydrogenase and glucuronidation. Ethanol may result in increased levels of abacavir through the inhibition of alcohol dehydrogenase.
How many protease inhibitors are there?
There are ten HIV protease inhibitors approved by the FDA; those inhibitors include: saquinavir, indinavir, ritonavir, nelfinavir, amprenavir, fosamprenavir, lopinavir, atazanavir, tipranavir, and darunavir (Figure 2).
What is the function of protease inhibitors?
Protease inhibitors, which figure among the key drugs used to treat HIV, work by binding to proteolytic enzymes (proteases). That blocks their ability to function. Protease inhibitors don’t cure HIV. But by blocking proteases, they can stop HIV from reproducing itself.
How do protease inhibitors interfere with the production of infectious viral particles quizlet?
Protease inhibitors interfere with HIV’s ability to make new viruses inside the CD4 cells. Specifically, they block an enzyme known as protease. Protease breaks down HIV proteins, using those smaller particles to make new viruses that can mature and spread.
What are some natural protease inhibitors?
Many researchers have classified these plant protease inhibitors into families such as Bowman-Birk, Kunitz, Potato I, Potato II, Serpine, Cereal, Rapeseed, Mustard, and Squash (Laskowski and Qasim, 2000; De Leo et al., 2002). Naturally occurring PIs are abundant in legume seeds.
Are there natural protease inhibitors?
Plants are good sources of protease inhibitors (PIs) which protect them against diseases, insects, pests, and herbivores. These natural PIs vary in concentration, protease specificity, heat stability, and sometimes several PIs may be present in the same species or tissue.
What are some examples of protease inhibitor drugs?
Here are some examples of protease inhibitor drug interactions. Protease inhibitor drugs may increase blood levels of the following drugs: alfuzosin (Uroxatral) doxazosin (Cardura) silodosin (Rapaflo) tamsulosin (Flomax) sildenafil (Viagra, Revatio)
Can a pregnant woman take a protease inhibitor?
Hepatitis C virus protease inhibitors have not been adequately evaluated in pregnant women or nursing mothers. The patient’s OB/GYN doctor should be consulted before protease inhibitors are used in a pregnant or nursing woman. Guidelines are available for the use of protease inhibitors in pregnant women, neonates, and children (see references).
How are protease inhibitors used to treat HIV?
Protease inhibitors (PIs) are antiviral drugs used for treating human immunodeficiency virus (HIV) infections and hepatitis C virus (HCV) infections. During infection with HIV or hepatitis C, the HIV or HCV multiply within the body’s cells. Viruses are released from the cells and spread throughout the body where they infect other cells.
Are there any natural protease inhibitors for green tea?
The natural protease inhibitors in green tea may suppress infection by other pathogens, such as the flu virus and the adenovirus 3 ⭐ . These pathogens commonly cause respiratory infection in children. Though more common in Asian cuisine than American, blue-green algae is a nutrient-dense food and supplement.