Does TB medicine cause depression?

Does TB medicine cause depression?

There is another aspect of TB and mental health connection, which is drug-induced psychosis. Several anti-TB medications like cycloserine may precipitate more severe forms of mental disorders—including major depression, anxiety or psychosis.

Does inactive TB need treatment?

Treatment of latent TB infection is essential to controlling TB in the United States because it substantially reduces the risk that latent TB infection will progress to TB disease. In the United States, up to 13 million people may have latent TB infection.

Does isoniazid cause depression?

Five cases developing psychosis while receiving isoniazid that presented with excessive argumentation, mental depression, euphoria, grandiose ideas, and complex delusions; none of these patients had any previous history of mental illness.

How does TB affect mental health?

With survivors speaking out more frequently about their experience of TB and mental health, there is evidence of depression, loneliness, anxiety and low self-esteem associated with the disease. Besides cases of drug-induced psychiatric symptoms, TB-related stigma can also have a debilitating effects on patients.

How can TB treatment affect patients emotionally and psychologically?

Additionally, TB treatment is long and mentally exhausting with numerous side effects. Several anti-TB medicines like cycloserine, which is used for drug resistant TB, cause mental health problems such as anxiety, or psychosis.

How long is latent TB treatment?

CDC and the National Tuberculosis Controllers Association (NTCA) preferentially recommend short-course, rifamycin-based, 3- or 4-month latent TB infection treatment regimens over 6- or 9-month isoniazid monotherapy. Short course regimens include: Three months of once-weekly isoniazid plus rifapentine (3HP)

Is isoniazid an antidepressant?

Isoniazid was thereafter widely prescribed for depression: hepatotoxicity ending its use as an antidepressant in 1961. Isoniazid monotherapy led to the emergence of drug resistant tuberculosis, stimulating new drug development.

What psychiatric condition can isoniazid cause?

Adverse effects include hepatitis, peripheral neurotoxicity, lupus like syndrome, and central nervous system effects including dysarthria, seizures, irritability and even psychosis [2]. Studies have found higher prevailing rates of mental illness, including psychosis in tuberculosis.

What TB drug is most likely to cause psychosis seizures and depression?

Some drugs used for MDR-TB treatment cause psychiatric disorder. Psychosis has been reported as a side effect of INH, ethambutol, fluoroquinolones, and CS. Depression psychosis has been reported as side effect primarily associated with CS.

How does tuberculosis affect mental health?

Patients with TB may suffer from mental disorders as a result of long-term treatment, anti-TB drug side effects and TB relapses (1, 2). Anxiety and depression are common mental disorders and global public health concerns.

How long does it take for depression to go away with TB?

Anti-TB treatment will progressively reduce depressive symptoms so that those with depression at baseline will have reduced severity of depression (Patient Health Questionnaire-9; PHQ-9 scores) or no depression after 2 and 6 months treatment for TB.

What are the treatment regimens for latent TB?

Treatment Regimens for Latent TB Infection (LTBI) † Rifapentine (RPT) is formulated as 150 mg tablets in blister packs that should be kept sealed until use. ‡ Intermittent regimens must be provided via directly observed therapy (DOT), that is, a health care worker observes the ingestion of medication.

When to use isoniazid rifapentine for latent TB?

Treatment must be modified if the patient is a contact of an individual with drug-resistant TB disease. Consultation with a TB expert is advised if the known source of TB infection has drug-resistant TB. CDC has updated the recommendations for use of once-weekly isoniazid-rifapentine for 12 weeks (3HP) for treatment of latent TB infection.

How is depression measured in patients with tuberculosis?

The primary exposure variable is probable depression measured using the Patient Health Questionnaire-9. Outcome variables include: pathways to treatment, classical outcomes for anti-TB treatment quality of life and disability. Descriptive statistics, logistic regression and multilevel mixed-effect analysis will be used to test the study hypotheses.

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