How do you memorize CYP450 inducers and inhibitors?

How do you memorize CYP450 inducers and inhibitors?

Cytochrome P450 (CYP450) enzymes can be inhibited or induced by some drugs, resulting in significant drug interactions that can cause unanticipated adverse reactions or therapeutic failures. An easy way to remember the mnemonic is; CRAP GPs spend all day on SICKFACES.com.

What are CYP450 inducers and inhibitors?

Drugs that cause CYP450 drug interactions are referred to as either inhibitors or inducers. This has the potential to cause drug interactions, thus increasing the risk of debilitating and even fatal adverse drug events. CYP450 inhibitors are used to minimize or prevent such reactions.

What do cytochrome p450 inducers do?

CYP enzyme inducers increase the rate of hepatic metabolism, usually through increased transcription of mRNA, and decrease serum concentrations of other drugs metabolized by the same hepatic isoenzyme.

What do CYP inducers do?

What does p450 enzyme do?

Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that functions as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown.

Which drugs are enzyme inducers?

Enzyme-inducing antiepileptic drugs

• Carbamazepine.
• Eslicarbazepine acetate.
• Oxcarbazepine.
• Perampanel (at a dose of 12 mg daily or more).
• Phenobarbital.
• Phenytoin.
• Primidone.
• Rufinamide.

What is the mnemonic crap for CYP450 inducers?

CYP450 inducers reduce the concentration of drugs metabolised by the CYP450 system. The mnemonic CRAP GPs can be used to easily remember common CYP450 inhibitors. CYP450 inhibitors increase the concentration of drugs metabolised by the CYP450 system.

How to remember enzyme inducers and enzyme inhibitors ( mnemonics )?

How to remember Enzyme inducers and Enzyme inhibitors (mnemonics) Enzyme inducers will increase the rate of metabolism of co-administered drugs and thus their effect will decrease or will be at lower therapeutic dose. As a result, the dose of such drugs (which are metabolized by microsomal enzymes) should be increased when administered along…

Are there any drugs that cause enzyme induction?

As you can see most of the antiepileptic drugs cause enzyme Induction, just like inducing an episode of epilepsy! What are the Enzyme Inhibitors?

Why do you need to increase the dose of enzyme inducers?

As a result, the dose of such drugs (which are metabolized by microsomal enzymes) should be increased when administered along with enzyme inducers. Enzyme inhibitors will decrease the metabolism of drugs metabolized by microsomal enzymes, thus predisposes to the toxicity by such agents.