Which is better vancomycin or linezolid?

Which is better vancomycin or linezolid?

Vancomycin has been the standard of care for nosocomial MRSA pneumonia infections, but several recent studies have suggested that linezolid may be superior to vancomycin in treating these infections4–7, which could be due to suboptimal penetration of vancomycin into the lungs at therapeutic doses.

When do you use linezolid instead of vancomycin?

Although linezolid is effective against mild-to-moderate MRSA infection, routine use for this purpose should be avoided to avert emergence of linezolid-resistant VRE. Vancomycin has been the treatment of choice for methicillin-resistant Staphylococcus aureus (MRSA) infections.

Is linezolid stronger than vancomycin?

Linezolid outcomes (124/140 patients or 88.6%) were superior to vancomycin outcomes (97/145 patients or 66.9%) at the TOC visit for patients with MRSA infections (P < 0.001). Drug-related adverse events were reported in similar numbers in both the linezolid and the vancomycin arms of the trial.

Can you use linezolid for bacteremia?

Linezolid is a synthetic oxazolidinone antimicrobial drug. It is indicated for gram-positive infections and approved for the treatment of bacterial pneumonia, skin and skin structure infections, and vancomycin-resistant enterococcal (VRE) infections, including infections complicated by bacteremia.

What are the side effects of linezolid?

What Are Side Effects Associated with Using Linezolid?

• diarrhea.
• vomiting.
• headache.
• red blood cell deficiency.
• low blood platelet count.
• nausea.
• abdominal pain.
• loose stools.

Is linezolid only IV?

In adults and children over the age of 12, linezolid is usually given every 12 hours, whether orally or intravenously. In younger children and infants, it is given every eight hours.

Can we give vancomycin and linezolid together?

Although linezolid may provide an alternative for patients who are intolerant to vancomycin or perhaps serve as a transition from vancomycin therapy to an oral antibiotic, our data suggest that linezolid should probably not be given together with vancomycin, as the combination was less effective than vancomycin alone.

Is MRSA resistant to linezolid?

Both MRSA and MSSA showed high resistance towards linezolid when using the disc diffusion method, with the figures being 48.1 and 29.2 %, respectively. The figures for the E-test were 46.3 and 27.0 %, respectively. The vancomycin resistance was remarkable in MRSA (14.8 %), but relatively low in MSSA (3.1 %).

What is similar to linezolid?

Many alternatives for the treatment of MRSA infections, including linezolid, daptomycin, tigecycline, and quinupristin/dalfopristin, are currently approved by the US Food and Drug Administration (FDA). Additionally, there are several investigational compounds with demonstrated in vitro activity against MRSA.

Does linezolid cover MRSA bacteremia?

Linezolid has in vitro activity against both MSSA and MRSA. Clinical activity has been confirmed in many types of infections including nosocomial pneumonia,9,10 ventilator-associated pneumonia,11 complicated skin and soft tissue infections,12 and MRSA infections.

How do you get MRSA bacteremia?

MRSA is usually spread in the community by contact with infected people or things that are carrying the bacteria. This includes through contact with a contaminated wound or by sharing personal items, such as towels or razors, that have touched infected skin.

What can be used instead of linezolid?

Treatment with trimethoprim-sulfamethoxazole plus rifampicin was found to be more cost-effective than linezolid in the base case and remained dominant over linezolid in most alternative scenarios, including different types of MRSA infection and potential disadvantages in terms of toxicity.

When to switch from vancomycin to linezolid for MRSA?

In patients with persistent (≥7 days) MRSA bacteremia while receiving vancomycin for at least 5 days, a switch to linezolid therapy led to similar outcomes as seen in those in whom vancomycin was continued. Linezolid resistance and linezolid failure have been described.

Which is better linezolid or vancomycin for Staphylococcus aureus?

In the multivariate analysis, treatment group was not a significant predictor of clinical cure or survival. Conclusions: Linezolid was associated with outcomes that were not inferior to those of vancomycin in patients with secondary S. aureus bacteraemia. Bacteraemia due to Staphylococcus aureus is a growing problem.

Is there an alternative to vancomycin for S.aureus?

Linezolid has been suggested as an alternative to vancomycin in patients with S. aureus bacteraemia, but few data are available describing the efficacy of linezolid in this setting. Consequently, some clinicians may have concerns about the efficacy of linezolid when the blood culture is positive for S. aureus.

Which is better vancomycin or daptomycin for MRSA?

Daptomycin is an acceptable alternative to vancomycin for treatment of MRSA bacteremia. Historically, daptomycin has been used as salvage therapy in patients failing vancomycin therapy, particularly with high vancomycin MIC infections, but increasingly it is being used as initial therapy in high inoculum MRSA infections.