What does an indican test show?
The production of indican reflects bacterial overgrowth in the small and large intestines, and may be an indicator of intestinal toxemia and overgrowth of anaerobic bacteria. A positive test may also indicate Hypochlorhydria (low stomach acid), or the malabsorption of protein.
Is indican normal in urine?
Most indoles are excreted in the feces. The remainder is absorbed, metabolized by the liver, and excreted as indicanin the urine. Indican normally appears in urine only at low levels, since it’s not normally produced in the cells of your body.
What are the other tests used to determine indican in the urine?
Miscellaneous Tests These include the nitrosonaphthol test, urinary indican excretion, bacterial release of sulfapyridine from sulfasalazine, and bacterial release of paraaminobenzoic acid (PABA) from a bile salt conjugate (PABA-UDCA [ursodeoxycholic acid]).
What are the conditions that result in high or increased indican levels in urine?
Among the different conditions in which urinary indican is likely elevated are hypochlorhydria (low stomach acid production), inhibited peristaltic movement (the involuntary muscular “waves” that move food through your bowel), and poor production of digestive bile secretions from the gall bladder and liver.
What is the importance of detecting indican in the urine?
The Urinary Indican Test is a simple-to-use point-of-care screening tool that allows for assessment ofdysbiosis, SIBO and malabsorption states as evidenced by the presence of indican.
How does indican occur in urine?
Tryptophan is first converted to indole, then to indican by bacteria in the gut. Indican is then excreted into the urine and from there into the diaper where, upon exposure to air, it is converted to indigo blue dye due to oxidation by atmospheric oxygen.
What is the significance of indican in the urine?
What does indican mean?
1 : an indigo-forming substance C8H7NO4S found as a salt in urine and other animal fluids also : its potassium salt C8H6KNO4S. 2 : a glucoside C14H17NO6 occurring especially in the indigo plant and being a source of natural indigo.
What is indican what is its significance in urine?
Medical significance Normal urine reacting to hydrogen peroxide does at times produce a bluish tinge. Tryptophan is first converted to indole (excreted in faeces), then to indican by bacteria in the gut. Indican, being water-soluble, is then excreted through the urine.
How is indican formed?
Indican is produced from tryptophan in a manner reminiscent of the production of p-cresol sulfate from tyrosine and phenylalanine. Gut bacteria convert tryptophan to indole, which is then oxidized to indoxyl and conjugated with sulfate in the liver.
What is the other name of indican?
Alternative name: potassium indoxylsulphate; chemical formula C₈H₆NOSO₂OH. ‘We have studied the effect of indican on six commercial procedures for the measurement of total bilirubin in serum. ‘
What is another name for indican?
A potassium salt present in urine, in which it occurs as a product of the metabolism of indole. Alternative name: potassium indoxylsulphate; chemical formula C₈H₆NOSO₂OH.
How do you test for indican in urine?
Only need to pipette 2 mL urine into the ready reagent vial, mix and read the indican level from a color chart. Indican (indoxyl sulfate) is a putrefaction product resulting from bacterial deconjugation of dietary tryptophan to indole in the small intestine. Indican levels are directly associated with bacterial activity in the intestines.
How is the bioassay system urinary Indican test?
BioAssay Systems’ Urinary Indican Test Kit is a less hazardous modification of the original Obermeyer indican reagent. It provides an accurate, simple, fast (15 min), and inexpensive screening tool for the identification of protein putrefaction in the gastrointestinal tract.
How does Dr Brody test for indican levels?
Dr. Brody likes to combine indican testing with a microbiome analysis to get a clearer picture of the underlying cause of your symptoms. Urinary Indican levels have been used for some time as a simple test for protein maldigestion. In the past, it has been measured with a color comparison chart which is graded 1-4.
How is indican produced in the upper bowel?
Indican is produced as a by-product by the dietary breakdown of an amino acid called tryptophan. Bacteria in the upper bowel facilitate this conversion from any unabsorbed tryptophan. Indican is normally low in healthy people and increased levels indicate small intestinal bacterial overgrowth (SIBO) or intestinal dysbiosis.