What is the function of Jak?
The JAK-STAT pathway in cytokine receptor signalling can activate STATs, which can bind to DNA and allow the transcription of genes involved in immune cell division, survival, activation and recruitment. For example, STAT1 can enable the transcription of genes which inhibit cell division and stimulate inflammation.
What happened to the lurkers?
After The Precursor Legacy After the supposed death of Gol and Maia, the Lurkers’ future is unknown. They evidently survived the Metal Head Wars as babaks, lurker sharks, and jungle fish were seen in the future.
Is the kid in Jak 2 Jak?
Jak as he appears in the opening cutscene of Jak II Between the end of The Precursor Legacy and the start of Jak II, Jak, Daxter, Keira, and Samos moved the Rift Rider and Rift Gate back to Sandover Village from the location of the large Precursor door.
How is JAK2 activated?
JAK2 activation is followed by tyrosine phosphorylation within the receptor cytoplasmic domain which generates docking sites for SH2 domain containing proteins such as STAT3 or STAT5, so that the docked protein is phosphorylated and activated.
What does JAK do in the body?
The JAK-STAT (Janus Kinase-Signal Transducer and Activator of Transcription) pathway mediates a variety of physiological processes including development, hematopoiesis, and inflammation. Although the JAK-STAT signaling pathway occurs in all cells, this pathway can mediate cell specific responses.
What does lurker mean?
In Internet culture, a lurker is typically a member of an online community who observes, but does not participate. Lurking allows users to learn the conventions of an online community before they participate, improving their socialization when they eventually “de-lurk”.
Who is the main villain in Jak and Daxter?
Gol Acheron Gol is the main antagonist in Jak & Daxter: The Precursor Legacy.
What is Eco in Jak and Daxter?
Green eco contains the energy of life. Jak used it throughout the games to heal himself after taking damage. It was also used to cure dark plants in The Precursor Legacy and Jak 3.
How old is Keira in Jak and Daxter?
Keira made her debut in The Precursor Legacy at fourteen years old, with her most recent known age at eighteen in Jak X: Combat Racing. During The Precursor Legacy and Jak II, Keira was voiced by Anna Garduno.