What is hydroxyl radical scavenging activity?
Hydroxyl radical is the most reactive oxygen centered species and causes severe damage to adjacent biomolecule. Hydroxyl radical scavenging activity was estimated by generating the hydroxyl radicals using ascorbic acid–iron EDTA.
What helps in scavenging of OH radical?
The antioxidant nordihydroguaiaretic acid (NDGA) is a plant phenolic lignan originally isolated from the creosote bush (Larrea tridentata). It has been shown that NDGA scavenges efficiently hydroxyl radicals (•OH).
How do radical scavengers work?
Free radical scavengers either prevent reactive oxygen species from being formed, or remove them before they can damage vital components of the cell. They are known as preventive and chain breaking antioxidants. This group includes physiological antioxidants like ascorbic acid, α tocopherol and β carotene.
What do hydroxyl radicals do in the body?
In a biological body, hydroxyl radicals attack the cell membrane, causing membrane damage and destroying sugar groups and DNA base sequences, inducing the disintegration of the double-helix structure, even causing cell death and mutations.
What is radical scavenger?
A free radical scavenger may also be known as an antioxidant, and refers to any molecule that’s stable enough to donate an electron to a free radical currently on a tear through your body, neutralizing it or reducing its capacity to do harm.
What is a radical scavenger?
A substance, such as an antioxidant, that helps protect cells from the damage caused by free radicals. Free radicals are unstable molecules that are made during normal cell metabolism (chemical changes that take place in a cell). They can build up in cells and cause damage to other molecules.
What are hydroxyl radicals?
The hydroxyl radical (HO•), the three-electron reduction product of molecular oxygen, is the most reactive species of oxygen. It has a half-life in biological systems of about 1 ns and reacts with organic molecules at rates that approach diffusion-limited, with rate constants of 109–1010 M−1 s−1 (Buxton et al. 1988).
Why is hydroxyl radical such an important component of the atmosphere?
Through chemical reactions, the OH hydroxyl radical acts to remove harmful trace gases from the troposphere. The short lifespan of OH makes it difficult to measure; it can prove easier to measure the trace gases it attacks.
What is the scavenging rate of hydroxyl radicals?
The scavenging rate of hydroxyl radicals amounted to 17.5% at a 2% protein concentration and continuously increased as sweet potato protein concentration increased. When sweet potato protein concentration was 6%, the scavenging rate reached 91.5% and was maintained at a similar level at higher concentrations ( Fig. 2.17 ).
How many hydroxyl radicals are in sweet potato?
Sweet potato protein has a strong hydroxyl radical scavenging activity. The scavenging rate of hydroxyl radicals amounted to 17.5% at a 2% protein concentration and continuously increased as sweet potato protein concentration increased.
Why are hydroxyl radicals important in radiation chemistry?
Hydroxyl radical. It is also an important radical formed in radiation chemistry, since it leads to the formation of hydrogen peroxide and oxygen, which can enhance corrosion and SCC in coolant systems subjected to radioactive environments. Hydroxyl radicals are also produced during UV-light dissociation of H 2 O 2 (suggested in 1879)…
Is the OH radical scavenging capacity of CRF serum restored?
We show for the first time that after hemodialysis, OH radical scavenging capacity of the CRF serum was restored to the level of healthy control.