What premedication should be recommended for paclitaxel?
Purpose: Dexamethasone and histamine antagonists have been employed commonly as premedications for prophylaxis of hypersensitivity reactions (HSRs) to paclitaxel. Frequent premedications for weekly administration of paclitaxel are associated with added side-effects and extra cost.
What are the ingredients of paclitaxel?
Each vial contains Paclitaxel, PEG-35 castor oil, anhydrous citric acid and absolute ethanol. Paclitaxel is a natural product with antitumour activity. It is a white to off white crystalline powder that is highly lipophilic and insoluble in water.
What is paclitaxel injection used for?
PACLITAXEL (PAK li TAX el) is a chemotherapy drug. It targets fast dividing cells, like cancer cells, and causes these cells to die. This medicine is used to treat ovarian cancer, breast cancer, lung cancer, Kaposi’s sarcoma, and other cancers.
What is the antidote for paclitaxel?
Sodium thiosulfate: It is an antidote generally recommended for mechlorethamine (nitrogen mustard) extravasation.
What are the side effects of paclitaxel?
Nausea, vomiting, diarrhea, mouth sores, muscle/joint pain, numbness/tingling/burning of the hands/feet, flushing, dizziness, or drowsiness may occur. If any of these effects persist or worsen, tell your doctor promptly. Temporary hair loss may occur.
Can paclitaxel stop normal cells from growing?
30, 31 Using the Caco-2 cancer cell line, we found that paclitaxel at low doses (1 × 10−9−10−8) steadily decreased cell growth over 2 days by 62% and 52%, respectively (Fig.
How do you feel after paclitaxel?
You might have a mild allergic reaction during or shortly after treatment. You might have itching, rash or red face. You will usually be given medication just before treatment to prevent or reduce risk of an allergic reaction.
What is the difference between paclitaxel and nab paclitaxel?
Paclitaxel is solvent-based and formulated in a mixture of polyoxyethylated castor oil (Kolliphor® EL, formerly known as Cremophor® EL; BASF, Ludwigshafen, Germany) and dehydrated alcohol, while nab-paclitaxel is an albumin-bound nanoparticle formulation of paclitaxel and is free of solvents.
How long does paclitaxel stay in the body?
The chemotherapy itself stays in the body within 2 -3 days of treatment but there are short-term and long-term side effects that patients may experience. Not all patients will experience all side effects but many will experience at least a few.
Why is paclitaxel given weekly?
The rationale for dose-dense weekly paclitaxel in the treatment of breast cancer is that more frequent delivery of more moderate doses may achieve greater efficacy than larger doses given less often through more sustained exposure of dividing tumor cells to cytotoxic drugs.
Does paclitaxel affect heart?
Paclitaxel-induced cardiotoxicity occurs either indirectly following a massive histamine release with subsequent conduction disturbances and arrhythmia, or through direct myocardial damage via an effect on subcellular organelles, which may induce congestive heart failure (CHF) [9, 10].
¿Cuál es la dosis recomendada de paclitaxel?
La dosis recomendada de paclitaxel es de 220 mg/m2administrados por vía intravenosa durante un periodo de tres horas, con un intervalo de tres semanas entre ciclos (ver secciones 4.5 y 5.1). Cuando se utiliza en combinación con trastuzumab, la dosis recomendada de paclitaxel es de 175 mg/m2.
¿Cómo se usa paclitaxel en el tratamiento del cáncer de mama?
Paclitaxel se usa en el tratamiento del cáncer de mama, ovario y pulmón. También es usado para tratar el sarcoma de Kaposi relacionado con el SIDA. Paclitaxel a veces se administra después que otros tratamientos fallaron. Paclitaxel puede también usarse para fines no mencionados en esta guía del medicamento.
¿Cómo se usa paclitaxel para tratar el cáncer de pulmón?
El paclitaxel (con aceite de ricino polioxietilado) se utiliza solo o con otros medicamentos de quimioterapia para tratar cáncer de seno, cáncer de ovarios (cáncer que comienza en los órganos reproductivos femeninos donde se forman los óvulos) y cáncer de pulmón de células no pequeñas (NSCLC, en inglés).
¿Cuándo se usa paclitaxel para tratar el cáncer de seno?
Cuando se utiliza paclitaxel (con aceite de ricino polioxietilado) para tratar el cáncer de seno, cáncer de ovarios o cáncer de pulmón de células no pequeñas, generalmente se administra cada 3 semanas. Cuando el paclitaxel (con aceite de ricino polioxietilado) se utiliza para tratar el sarcoma de Kaposi, se debe administrar cada 2 o 3 semanas.